Arterial Pulse Signal Amplification by Adding a Uniform PDMS Layer to a Pyrex-Based Microfluidic Tactile Sensor
Arterial Pulse Signal Amplification by Adding a Uniform PDMS Layer to a Pyrex-Based Microfluidic Tactile Sensor
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DOI：
10.1109/jsen.2019.2949503
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发表时间：
2020-02
影响因子：
4.3
通讯作者：
Z. Hao;Dan Wang
中科院分区：
文献类型：
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作者：
Z. Hao;Dan Wang
已经开发了基于微/纳米制造技术的各种柔性触觉传感器，以放大测量的脉搏信号以获得准确性。然而，这些传感器具有复杂的配置和制造复杂性。本工作的目的是调查的可行性，通过添加一个均匀的聚二甲基硅氧烷（PDMS）层的Pyrex为基础的微流体触觉传感器放大测量的脉冲信号。该方法的放大机制是由传感器-动脉相互作用的理论揭示。首先在没有均匀层的情况下，然后在具有不同PDMS混合比例和厚度的一组均匀层的情况下，通过传感器测量一个对象的皮肤下深处的桡动脉（RA）和皮肤附近的颞浅动脉（STA）处的脉搏信号。动脉参数：弹性，粘度和半径，估计从测量的脉搏信号。与没有均匀层的测量结果相比，均匀层在跨壁压（$\text{P}_{\text {T}}$）接近零时产生脉搏信号，极大地放大了两条动脉处的测量脉搏信号，导致估计的动脉弹性适度增加，并且对估计的动脉粘度和半径的影响可以忽略不计。由于它们的解剖学差异，脉搏信号放大归因于RA处组织传感器界面处的改善的脉搏传输和STA处的真实脉搏信号的减轻的抑制。覆盖组织和一个均匀的层上估计动脉参数的效果进行了进一步讨论。所提出的解决方案提供了一种低成本的解决方案，以获得接近零的放大脉冲信号，用于CV健康评估。
Various flexible tactile sensors based on micro/nano-fabrication technology have been developed to amplify a measured pulse signal for accuracy. Yet, these sensors suffer from complicated configurations and fabrication complexity. This work is aimed to investigate the feasibility of amplifying a measured pulse signal by adding a uniform polydimethylsiloxane (PDMS) layer to a Pyrex-based microfluidic tactile sensor. The amplifying mechanism of the proposed approach is revealed by theories on sensor-artery interaction. The pulse signals at the radial artery (RA) deep under the skin and the superficial temporal artery (STA) near the skin of one subject are measured by the sensor first with no uniform layer and then with a set of uniform layers with different mixing ratios of PDMS and thickness. Arterial parameters: elasticity, viscosity and radius, are estimated from the measured pulse signals. As compared to those measured with no uniform layer, a uniform layer generates a pulse signal at transmural pressure ( $\text{P}_{\text {T}}$ ) near zero, greatly amplifies the measured pulse signal at both arteries, causes a moderate increase in estimated arterial elasticity, and has negligible effect on estimated arterial viscosity and radius. Due to their anatomical difference, pulse signal amplification is attributed to improved pulse transmission at tissue-sensor interface at the RA and alleviated suppression of the true pulse signal at the STA. The effect of overlying tissue and a uniform layer on estimated arterial parameters is further discussed. The proposed solution offers a low-cost solution to acquiring an amplified pulse signal at $\text{P}_{\text {T}}$ near zero for CV health assessment.