Electrocardiographic Findings and Clinical Outcome in Patients with COVID-19 or Other Acute Infectious Respiratory Diseases.
Electrocardiographic Findings and Clinical Outcome in Patients with COVID-19 or Other Acute Infectious Respiratory Diseases.
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DOI：
10.3390/jcm9113647
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发表时间：
2020-11-12
影响因子：
3.9
通讯作者：
Lanza GA
中科院分区：
文献类型：
--
作者：
De Vita A;Ravenna SE;Covino M;Lanza O;Franceschi F;Crea F;Lanza GA
背景据报道，相当大比例的患者发生冠状病毒SARS-CoV-2感染（COVID-19）的心脏受累，并与阴性结局相关;此外，既存心脏病与这些患者的死亡率增加相关。在这项前瞻性单中心病例对照研究中，我们调查了COVID-19患者与其他病原体引起的急性传染性呼吸道疾病（AIRD）患者相比，心电图（ECG）异常的发生率和临床意义是否不同。方法.我们研究了我院急诊科收治的556名有AIRD症状的连续患者; 324名被诊断为COVID-19，232名为其他原因的AIRD（非COVID-19组）。入院时进行标准12导联ECG评估各种异常，包括ST段/T波改变、房颤、室性心律失常和室内传导障碍。结果COVID-19和非COVID-19组分别有120例（37.0%）和101例（43.5%）发现ECG异常（p = 0.13）。校正临床和实验室变量后，两组之间的ECG异常无差异。在45 ± 16天的随访期间，COVID-19组发生51例死亡（15.7%），非COVID-19组发生30例死亡（12.9%）（p = 0.39）。在多变量考克斯回归分析中，ST段压低≥ 0.5 mm（p = 0.016）、QRS时限（p = 0.016）和存在任何ECG异常（p = 0.027）与死亡率独立相关。结论在因AIRD住院的患者中，我们发现COVID-19与非COVID-19患者之间的异常ECG结果无显著差异。入院时的ECG有助于识别两组患者中死亡风险增加的患者。
Background. Cardiac involvement in coronavirus SARS-CoV-2 infection (COVID-19) has been reported in a sizeable proportion of patients and associated with a negative outcome; furthermore, a pre-existing heart disease is associated with increased mortality in these patients. In this prospective single-center case-control study we investigated whether COVID-19 patients present different rates and clinical implications of an abnormal electrocardiogram (ECG) compared to patients with an acute infectious respiratory disease (AIRD) caused by other pathogens. Methods. We studied 556 consecutive patients admitted to the emergency department of our hospital with symptoms of AIRD; 324 were diagnosed to have COVID-19 and 232 other causes of AIRD (no-COVID-19 group). Standard 12-lead ECG performed on admission was assessed for various kinds of abnormalities, including ST segment/T wave changes, atrial fibrillation, ventricular arrhythmias, and intraventricular conduction disorders. Results. ECG abnormalities were found in 120 (37.0%) and 101 (43.5%) COVID-19 and no-COVID-19 groups, respectively (p = 0.13). No differences in ECG abnormalities were found between the 2 groups after adjustment for clinical and laboratory variables. During a follow-up of 45 ± 16 days, 51 deaths (15.7%) occurred in the COVID-19 and 30 (12.9%) in the no-COVID-19 groups (p = 0.39). ST segment depression ≥ 0.5 mm (p = 0.016), QRS duration (p = 0.016) and presence of any ECG abnormality (p = 0.027) were independently associated with mortality at multivariable Cox regression analysis. Conclusion. Among patients hospitalized because of AIRD, we found no significant differences in abnormal ECG findings between COVID-19 vs. no-COVID-19 patients. The ECG on admission was helpful to identify patients with increased risk of death in both groups of patients.
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影响因子：
24
作者：
Rautaharju, Pentti M.;Surawicz, Borys;Gettes, Leonard S.
通讯作者：
Gettes, Leonard S.
DOI：
10.15557/pimr.2020.0003
发表时间：
2020-01-01
影响因子：
3.6
作者：
通讯作者：
--
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
8.3
作者：
Frencken, Jos F.;van Baal, Lottie;Koster-Brouwer, Maria E.
通讯作者：
Koster-Brouwer, Maria E.
影响因子：
6.1
作者：
Lanza, Gaetano Antonio;De Vita, Antonio;Crea, Filippo
通讯作者：
Crea, Filippo