Anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid: physiologic uptake patterns, incidental findings, and variants that may simulate disease.
Anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid: physiologic uptake patterns, incidental findings, and variants that may simulate disease.
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抗-1-Amino-3-18F-氟西丁烷-1-羧酸：生理摄取模式，偶然发现和可能模拟疾病的变体。
DOI：
10.2967/jnumed.114.143628
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Goodman MM
中科院分区：
文献类型：
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作者：
Schuster DM;Nanni C;Fanti S;Oka S;Okudaira H;Inoue Y;Sörensen J;Owenius R;Choyke P;Turkbey B;Bogsrud TV;Bach-Gansmo T;Halkar RK;Nye JA;Odewole OA;Savir-Baruch B;Goodman MM
抗-1-氨基-3-18 F-氟环丁烷-1-羧酸（18 F-FACBC）是一种合成氨基酸类似物PET放射性示踪剂，正在进行临床试验，用于评估前列腺癌和其他癌症。我们的目的是描述接受18F-FACBC PET的患者的常见生理摄取模式、偶然发现和变异。回顾了6个中心的16项临床试验，涉及611项18F-FACBC研究，其中包括12名健康志愿者的剂量学研究。记录常见生理模式、偶然摄取和可能模拟疾病的变体的定性观察结果，并与健康志愿者研究中的类似观察结果进行比较。还对选定的数据进行了定量分析，并对先前发表的报告和观察结果进行了审查。肝脏和胰腺的吸收最强烈。通常可见中度唾液和垂体摄取和可变的轻度至中度肠道活动。在早期图像上出现中度骨髓和轻度肌肉活动，随着时间的推移，骨髓活动减少，肌肉活动增加。脑和肺的活性低于血池。尽管18F-FACBC在临床有用的早期成像时间窗内显示出很少的肾脏排泄或膀胱摄取，但轻度至中度活性可能在膀胱中蓄积，并干扰5%-10%患者的相邻前列腺床和精囊的评价。摄取也可能发生在良性过程中，如感染、炎症、前列腺增生和代谢活跃的良性骨病变，如骨样骨瘤。常见的生理摄取模式与健康志愿者中观察到的相似。器官中的活性遵循其他基于氨基酸的PET放射性示踪剂所描述的氨基酸转运和代谢的存在。与其他PET放射性示踪剂如18F-FDG一样，局灶性非生理性摄取可能代表偶发恶性肿瘤。也发生了与生理背景不同的良性病因引起的摄取，如果读者不知道，可能导致误解。
Anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid (18F-FACBC) is a synthetic amino acid analog PET radiotracer undergoing clinical trials for the evaluation of prostate and other cancers. We aimed to describe common physiologic uptake patterns, incidental findings, and variants in patients who had undergone 18F-FACBC PET. Sixteen clinical trials involving 611 18F-FACBC studies from 6 centers, which included dosimetry studies on 12 healthy volunteers, were reviewed. Qualitative observations of common physiologic patterns, incidental uptake, and variants that could simulate disease were recorded and compared with similar observations in studies of the healthy volunteers. Quantitative analysis of select data and review of prior published reports and observations were also made. The liver and pancreas demonstrated the most intense uptake. Moderate salivary and pituitary uptake and variable mild to moderate bowel activity were commonly visualized. Moderate bone marrow and mild muscle activity were present on early images, with marrow activity decreasing and muscle activity increasing with time. Brain and lungs demonstrated activity less than blood pool. Though 18F-FACBC exhibited little renal excretion or bladder uptake during the clinically useful early imaging time window, mild to moderate activity might accumulate in the bladder and interfere with evaluation of adjacent prostate bed and seminal vesicles in 5%–10% of patients. Uptake might also occur from benign processes such as infection, inflammation, prostatic hyperplasia, and metabolically active benign bone lesions such as osteoid osteoma. Common physiologic uptake patterns were similar to those noted in healthy volunteers. The activity in organs followed the presence of amino acid transport and metabolism described with other amino acid–based PET radiotracers. As with other PET radiotracers such as 18F-FDG, focal nonphysiologic uptake may represent incidental malignancy. Uptake due to benign etiologies distinct from physiologic background also occurred and could lead to misinterpretations if the reader is unaware of them.