Adiponectin expression is decreased in the involved skin and sera of diffuse cutaneous scleroderma patients
Adiponectin expression is decreased in the involved skin and sera of diffuse cutaneous scleroderma patients
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DOI：
10.1111/j.1600-0625.2011.01310.x
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发表时间：
2011-09-01
影响因子：
3.6
通讯作者：
Ihn, Hironobu
中科院分区：
文献类型：
--
作者：
Arakawa, Hiroki;Jinnin, Masatoshi;Ihn, Hironobu
本研究测定了硬皮病（SSc）患者血清和病变皮肤中脂联素的表达。采用特异性酶联免疫吸附法测定32例SSc患者、10例SLE患者、12例皮肌炎患者和13例健康人的血清脂联素浓度。采用实时聚合酶链反应测定5例弥漫性皮肤SSc （dcSSc）、7例局限性皮肤SSc （lcSSc）和7例健康受试者皮肤组织中脂联素mRNA的含量。dcSSc患者血清脂联素水平显著降低。SSc患者血清脂联素水平降低，总皮肤厚度评分较高，肺纤维化发生率较高。dcSSc患者皮肤组织中脂联素mRNA水平也降低。血清脂联素水平可能是SSc患者纤维化状况的有用生物标志物。阐明脂联素在胶原蛋白疾病中的作用，有助于进一步认识其发病机制和新的治疗方法。
In this study, we determined the adiponectin expression in the serum and lesional skin of patients with scleroderma (SSc). Serum adiponectin concentrations were measured in 32 patients with SSc, 10 patients with SLE, 12 patients with dermatomyositis patients and 13 healthy subjects with specific enzyme-linked immunosorbent assays. Adiponectin mRNA was determined in skin tissues of five patients with diffuse cutaneous SSc (dcSSc), seven patients with limited cutaneous SSc (lcSSc) and seven healthy subjects with real-time polymerase chain reaction. There was a significant reduction in serum adiponectin levels in patients with dcSSc. SSc patients with decreased serum adiponectin levels had higher total skin thickness score and higher incidence of pulmonary fibrosis. Adiponectin mRNA levels in skin tissues from patients with dcSSc were also reduced. Serum adiponectin levels may be a useful biomarker for fibrotic condition in patients with SSc. Clarifying the role of adiponectin in collagen diseases may lead to further understanding of the pathogenesis and new therapeutic approach.