Novel drug delivery system of hollow mesoporous silica nanocapsules with thin shells: preparation and fluorescein isothiocyanate (FITC) release kinetics.
Novel drug delivery system of hollow mesoporous silica nanocapsules with thin shells: preparation and fluorescein isothiocyanate (FITC) release kinetics.
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DOI：
10.1016/j.colsurfb.2007.03.005
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发表时间：
2007-08
期刊：
影响因子：
--
通讯作者：
Yiyao Liu;H. Miyoshi;Michihiro Nakamura
中科院分区：
文献类型：
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作者：
Yiyao Liu;H. Miyoshi;Michihiro Nakamura
以40和50 nm的金纳米粒子为模板，合成了直径约为45- 60 nm、壁厚为3- 10 nm的核壳结构Au纳米粒子。介孔粒子通过3-氨丙基三甲氧基硅烷的添加来调节。采用氰化钠溶解金核的方法制备了中空介孔二氧化硅纳米胶囊。通过透射电子显微镜对Au@silica和HMSNs的表征表明，SiO2壳层均匀光滑，异硫氰酸荧光素（FITC）释放实验也证明了其多孔性。空心核占HMSNs的比例大于70%。以FITC为模型药物，研究了HMSNs的体外释药行为。进行荧光光谱法测定从HMSN的释放动力学。与对照（游离FITC）相比，释放曲线显著不同，这表明HMSNs是控制药物释放的良好药物载体，并且在未来的治疗药物递送应用中具有很高的潜力。
Core-shell nanoparticles of Au@silica with a diameter of approximate 45–60nm and wall thickness in range of 3–10nm were synthesized by using 40 and 50nm gold nanoparticles as the templates. The mesoporous particles are regulated by 3-aminopropyltrimethoxysilane addition. Hollow mesoporous silica nanocapsules (HMSNs) were prepared by using sodium cyanide to dissolve the gold cores. The characterization of Au@silica and HMSNs by transmission electronic microscope indicated that the silica shells were uniform and smooth, and also the porosity was proved by fluorescein isothiocyanate (FITC) release experiments. The ratio of hollow core to HMSNs is more than 70%. HMSNs were subsequently used as drug carrier to investigate FITC (as a model drug) release behaviors in vitro. Fluorescent spectrometry was performed to determine the release kinetics from the HMSNs. The release profiles are significantly different as compared with the control (free FITC), which show that HMSNs are good drug carriers to control drug release, and have high potential in therapeutic drugs delivery in future applications.