Epigenetic integration of environmental and genomic signals in honey bees
Epigenetic integration of environmental and genomic signals in honey bees
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DOI：
10.4161/epi.3.4.6697
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发表时间：
2008-07-01
期刊：
影响因子：
3.7
通讯作者：
Maleszka, Ryszard
中科院分区：
文献类型：
--
作者：
Maleszka, Ryszard
蜜蜂和其他昆虫中高度保守的DNA胞嘧啶甲基化酶家族的发现表明，与哺乳动物一样，无脊椎动物具有储存表观遗传信息的机制，该机制控制基因表达的可遗传状态。最近的数据还表明，沉默年轻幼虫中的DNA甲基化模拟了营养对决定蜜蜂雌性生殖命运的早期发育过程的影响。我们评估了这些发现对未来社会昆虫环境驱动的表型可塑性研究的影响，并讨论了它们如何有助于理解人类表观遗传重编程的营养基础。
The discovery of a family of highly conserved DNA cytosine methylases in honey bees and other insects suggests that, like mammals, invertebrates possess a mechanism for storing epigenetic information that controls heritable states of gene expression. Recent data also show that silencing DNA methylation in young larvae mimics the effects of nutrition on early developmental processes that determine the reproductive fate of honey bee females. We evaluate the impact of these findings on future studies of environmentally-driven phenotypic plasticity in social insects, and discuss how they may help in understanding the nutritional basis of epigenetic reprogramming in humans.