DNA pattern and cytological findings in fine‐needle aspirates of untreated prostatic tumors. A flow‐cytofluorometric study
DNA pattern and cytological findings in fine‐needle aspirates of untreated prostatic tumors. A flow‐cytofluorometric study
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未经治疗的前列腺肿瘤细针抽吸物的 DNA 模式和细胞学发现。流式细胞荧光研究。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
P. Esposti
中科院分区：
文献类型：
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作者：
L. Rönström;B. Tribukait;P. Esposti
The cellular DNA content in fine‐needle prostatic aspirates from 500 untreated patients was determined by flow cytofluorometry. According to the DNA patterns diploid, tetraploid, and non‐tetraploid aneuploid cases were identified. In 301 cytologically benign cases more than 90% showed diploid DNA patterns. Among 166 carcinomas the incidence of aneuploid DNA values increased with the degree of anaplasia, ie, 44% in well‐differentiated, 78% in moderately differentiated, and 97% in poorly differentiated tumors. In aneuploid cases of well‐differentiated carcinomas almost exclusively tetraploid DNA patterns were observed, while in poorly differentiated carcinomas about 80% showed non‐tetraploid aneuploid DNA distributions. Among aneuploid cases of moderately differentiated carcinomas 2/3 were tetraploid and 1/3 non‐tetraploid aneuploid. Morphologically similar tumors may thus be separated by the DNA profiles. The biological significance of these results must be further evaluated by clinical follow‐up of the patients.
