Lensfree sensing on a microfluidic chip using plasmonic nanoapertures
Lensfree sensing on a microfluidic chip using plasmonic nanoapertures
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DOI：
10.1063/1.3521390
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发表时间：
2010-11-29
影响因子：
4
通讯作者：
Ozcan, Aydogan
中科院分区：
文献类型：
--
作者：
Khademhosseinieh, Bahar;Biener, Gabriel;Ozcan, Aydogan
我们演示了在微流控通道内使用等离子体纳米孔的无透镜片上传感，该微流控通道由部分相干准单色源照射。在这种方法中，利用光电传感器阵列记录了位于微流体通道底部的金属纳米孔的无透镜衍射图案。使用相位恢复技术，这些无透镜衍射图可以快速处理，将光场反向传播到任意深度，从而创建数字聚焦的复杂传输图。这些模式的相互关联使得芯片上无透镜的局部折射率周围的近场等离子体纳米孔径传感。基于这一原理，我们实验证明了无透镜传感的折射率变化小到类似于2 × 10（-3）。这种片上传感方法可以通过在同一微流控芯片上复用数千个等离子体结构来开发无标签微阵列技术，这可以显着提高传感的吞吐量。(C) 2010年美国物理研究所。(doi: 10.1063/1.3521390)
We demonstrate lensfree on-chip sensing within a microfluidic channel using plasmonic nanoapertures that are illuminated by a partially coherent quasimonochromatic source. In this approach, lensfree diffraction patterns of metallic nanoapertures located at the bottom of a microfluidic channel are recorded using an optoelectronic sensor-array. These lensfree diffraction patterns can then be rapidly processed, using phase recovery techniques, to back propagate the optical fields to an arbitrary depth, creating digitally focused complex transmission patterns. Cross correlation of these patterns enables lensfree on-chip sensing of the local refractive index surrounding the near-field of the plasmonic nanoapertures. Based on this principle, we experimentally demonstrate lensfree sensing of refractive index changes as small as similar to 2 X 10(-3). This on-chip sensing approach could be quite useful for development of label-free microarray technologies by multiplexing thousands of plasmonic structures on the same microfluidic chip, which can significantly increase the throughput of sensing. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3521390]