Brain structural abnormalities in psychotropic drug-naive pediatric patients with obsessive-compulsive disorder
Brain structural abnormalities in psychotropic drug-naive pediatric patients with obsessive-compulsive disorder
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DOI：
10.1176/appi.ajp.161.6.1049
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发表时间：
2004-06-01
影响因子：
17.7
通讯作者：
Rosenberg, DR
中科院分区：
文献类型：
--
作者：
Szeszko, PR;MacMillan, S;Rosenberg, DR
目的：作者研究了强迫症（OCD）儿童患者大脑皮层-纹状体-丘脑-皮层环的结构异常。方法：尾状核，壳核，和苍白球以及前扣带回和上级额回的灰色和白色物质体积计算来自23名精神药物患者的连续1.5 mm磁共振图像，结果：强迫症患儿苍白球体积小于健康志愿者，但尾状核、壳核和额叶白色区体积与健康志愿者无显著差异。与健康志愿者相比，患者扣带回前部的灰质总量较多，但上级额回的灰质总量较少。总扣带回前部体积显着相关，与苍白球体积在健康志愿者，但不是在patients.Conclusions：这些研究结果提供了证据，较小的苍白球体积在强迫症患者没有潜在的混杂影响，以前的精神药物暴露。在前扣带回的体积异常出现特定的灰质强迫症，至少在大体解剖水平，并与功能性神经影像学研究的结果，报告前扣带回代谢亢进的疾病是一致的。
Objective: The authors investigated structural abnormalities in brain regions comprising cortical-striatal-thalamic-cortical loops in pediatric patients with obsessive-compulsive disorder (OCD).Method: Volumes of the caudate nucleus, putamen, and globus pallidus and gray and white matter volumes of the anterior cingulate gyrus and superior frontal gyrus were computed from contiguous 1.5-mm magnetic resonance images from 23 psychotropic drug-naive pediatric patients with OCD (seven male patients and 16 female patients) and 27 healthy volunteers (12 male subjects and 15 female subjects).Results: Patients had smaller globus pallidus volumes than healthy volunteers, but the two groups did not differ in volumes of the caudate nucleus, putamen, or frontal white matter regions. Compared to healthy volunteers, patients had more total gray matter in the anterior cingulate gyrus but not the superior frontal gyrus. Total anterior cingulate gyrus volume correlated significantly and positively with globus pallidus volume in the healthy volunteers but not in patients.Conclusions: These findings provide evidence of smaller globus pallidus volume in patients with OCD without the potentially confounding effects of prior psychotropic drug exposure. Volumetric abnormalities in the anterior cingulate gyrus appear specific to the gray matter in OCD, at least at the gross anatomic level, and are consistent with findings of functional neuroimaging studies that have reported anterior cingulate hypermetabolism in the disorder.