Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis
Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis
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DOI：
10.1016/s0140-6736(10)61272-x
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发表时间：
2010-12-04
期刊：
影响因子：
168.9
通讯作者：
Mikhailidis, Dimitri P.
中科院分区：
文献类型：
--
作者：
Athyros, Vasilios G.;Tziomalos, Konstantinos;Mikhailidis, Dimitri P.
背景长期他汀类药物治疗可以降低心血管事件的频率，但对肝脏检查异常患者的安全性和有效性尚不清楚。我们通过对希腊阿托伐他汀和冠心病评估（GREACE）研究人群的事后分析，评估他汀类药物治疗对这些患者是否安全有效。方法GREACE是一项前瞻性、意向性治疗研究，通过计算机生成的随机化列表随机分配1600例冠心病患者（年龄2.6 mmol/L，甘油三酯
Background Long-term statin treatment reduces the frequency of cardiovascular events, but safety and efficacy in patients with abnormal liver tests is unclear. We assessed whether statin therapy is safe and effective for these patients through post-hoc analysis of the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) study population.Methods GREACE was a prospective, intention-to-treat study that randomly assigned by a computer-generated randomisation list 1600 patients with coronary heart disease (aged 2.6 mmol/L and triglycerides