Peptide synthesis. Part 12. 3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl esters of fluorenylmethoxycarbonyl amino acids as self-indicating reagents for solid phase peptide synthesis
Peptide synthesis. Part 12. 3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl esters of fluorenylmethoxycarbonyl amino acids as self-indicating reagents for solid phase peptide synthesis
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肽合成。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
R. Valerio
中科院分区：
文献类型：
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作者：
E. Atherton;Jill L. Holder;M. Meldal;R. Sheppard;R. Valerio
本文描述了Fmoc-氨基酸的3，4-二氢-4-氧代-1，2，3-苯并三嗪基酯（1）的制备和表征及其在固相肽合成中的应用。释放的羟基组分（2）被起始树脂结合的胺电离提供了酰化反应进程的有用颜色指示剂。
The preparation and characterisation of 3,4-dihydro-4-oxo-1,2,3-benzotriazinyl esters (1) of Fmoc-amino acids and their use in solid phase peptide synthesis is described. Ionisation of the liberated hydroxy component (2) by the starting resin-bound amine provides a useful colour indicator of the progress of acylation reactions.