Effects of a partly self-administered exercise program before, during, and after allogeneic stem cell transplantation
Effects of a partly self-administered exercise program before, during, and after allogeneic stem cell transplantation
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DOI：
10.1182/blood-2010-09-306308
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发表时间：
2011-03-03
期刊：
影响因子：
20.3
通讯作者：
Bohus, Martin
中科院分区：
文献类型：
--
作者：
Wiskemann, Joachim;Dreger, Peter;Bohus, Martin
在异基因造血干细胞移植(allo-HSCT)之前、期间和之后，患者都会经历相当大的生理和心理痛苦。除了移植物抗宿主疾病和感染，体能下降和高度疲劳还会影响患者的生活质量。这项多中心随机对照试验研究了在allo-HSCT前、中、后进行部分自我管理的运动干预对这些副作用的影响。在随机分为锻炼组和社会接触对照组后，105名患者在入院前、住院治疗期间和出院后6至8周内在家庭环境中进行训练。在基线、入院、出院和出院后6~8周用标准化工具测量疲劳感、体能表现、生活质量和生理/心理困扰。运动组在疲劳分数(运动组提高了15%，而对照组恶化了28%；P<；.01-.03)、身体健康/功能(P=.02-.03)和整体苦恼(P=.03)方面有了显著改善。所有影响至少在住院或重复后的一个评估时间点可检测到。身体健康与所有报告的症状/变量显著相关。总之，这种部分监督的运动干预对接受allo-HSCT的患者是有益的。由于对人员的要求较低，将这种计划整合到标准医疗保健中可能是有价值的。(血。2011；117(9)：2604-2613)
Before, during, and after allogeneic hematopoietic stem cell transplantation (allo-HSCT), patients experience considerable physical and psychologic distress. Besides graft-versus-host disease and infections, reduced physical performance and high levels of fatigue affect patients' quality of life. This multicenter randomized controlled trial examined the effects of a partly self-administered exercise intervention before, during, and after allo-HSCT on these side effects. After randomization to an exercise and a social contact con-trol group 105 patients trained in a home-based setting before hospital admission, during inpatient treatment and a 6- to 8-week period after discharge. Fatigue, physical performance, quality of life, and physical/psychologic distress were measured by standardized instruments at baseline, admission to, and discharge from hospital and 6 to 8 weeks after discharge. The exercise group showed significantly improvement in fatigue scores (up to 15% improvement in exercise group vs up to 28% deterioration in control; P < .01-.03), physical fitness/functioning (P = .02-.03) and global distress (P = .03). All effects were at least detectable at one assessment time point after hospitalization or repeatedly. Physical fitness correlated significantly with all reported symptoms/variables. In conclusion, this partly supervised exercise intervention is beneficial for patients undergoing allo-HSCT. Because of low personnel requirements, it might be valuable to integrate such a program into standard medical care. (Blood. 2011; 117(9): 2604-2613)