SERUM AMYLOID A PROTEIN IN AMYLOIDOSIS, RHEUMATIC, AND NEOPLASTIC DISEASES
SERUM AMYLOID A PROTEIN IN AMYLOIDOSIS, RHEUMATIC, AND NEOPLASTIC DISEASES
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DOI：
10.1002/art.1780220106
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发表时间：
1979-01-01
影响因子：
--
通讯作者：
COHEN, AS
中科院分区：
文献类型：
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作者：
BENSON, MD;COHEN, AS
用~（125）I标记的AA和抗AA放射免疫法测定了不同类型的淀粉样变性病和风湿性疾病患者血清中的淀粉样蛋白A（SAA）水平。SAA水平在原发性和继发性淀粉样变性中升高，但这些水平之间存在非常显著的差异。在遗传性家族性淀粉样蛋白中，SAA水平在正常范围内。虽然平均SAA水平在70岁以上的人中升高，但这个年龄组中的一些人水平正常的事实表明，70岁后的显着升高可能是由于隐匿性炎症或肿瘤性疾病。类风湿性关节炎患者的高SAA水平通常与医生对疾病活动性和Westergren ESR的评估相关。系统性红斑狼疮患者的SAA水平低于类风湿关节炎患者，大多数退行性关节病患者的SAA水平正常。在肿瘤性疾病患者中发现非常高水平的SAA。肺癌和肠癌患者的水平比乳腺癌患者高得多。SAA水平的测定可能对评估不同形式的系统性淀粉样变性、评估风湿性疾病的活动性以及筛查隐匿性炎症或肿瘤性疾病有价值。
Serum levels of amyloid protein A (SAA) were elevated in different types of amyloidosis and in rheumatic diseases by radioimmunoassay using 125I-labeled AA and anti-AA. SAA levels were elevated in primary and secondary amyloidosis, but there were highly significant differences between these levels. In hereditary familial amyloid, SAA levels were within normal limits. While the mean SAA level was elevated in persons over 70 yr, the fact that some persons in this age group had normal levels suggested that marked elevation after age 70 may be due to occult inflammatory or neoplastic disease. High SAA levels in patients with rheumatoid arthritis usually correlated with physician evaluation of disease activity and Westergren ESR. SAA levels in patients with systemic lupus erythematosus were lower than those in patients with rheumatoid arthritis, and most patients with degenerative joint disease had normal levels. Very high levels of SAA were found in patients with neoplastic diseases. Patients with carcinoma of the lung and bowel had much higher levels than patients with carcinoma of the breast. Determination of SAA levels may be of value in evaluating different forms of systemic amyloidosis, assessing the activity of rheumatic disease, and screening for occult inflammatory or neoplastic disease.