Libertellenones A-D: Induction of cytotoxic diterpenoid biosynthesis by marine microbial competition
Libertellenones A-D: Induction of cytotoxic diterpenoid biosynthesis by marine microbial competition
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DOI：
10.1016/j.bmc.2005.05.068
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发表时间：
2005-09-01
影响因子：
3.5
通讯作者：
Fenical, W
中科院分区：
文献类型：
--
作者：
Oh, DC;Jensen, PR;Fenical, W
将海洋α-变形菌添加到海洋源性真菌 Libertella sp 的既定培养物中后，观察到四种新二萜类化合物生物合成的诱导。单独培养的真菌菌株和海洋细菌不产生二萜代谢物。诱导的二萜类化合物 libertellenones A-D 是哌玛烷类的交叉共轭酮。 libertellenones 对 HCT-116 人腺癌细胞系表现出不同水平的细胞毒性，其中 libertellenone D 最为有效（IC50 = 0.76 μM）。 (c) 2005 Elsevier Ltd. 保留所有权利。
The induction of biosynthesis of four new diterpenoids was observed following the addition of a marine alpha-proteobacterium to an established culture of the marine-derived fungus Libertella sp. The fungal strain and the marine bacterium, cultured alone, do not produce diterpenoid metabolites. The induced diterpenoids, libertellenones A-D, are cross-conjugated ketones of the pimarane class. The libertellenones show varying levels of cytotoxicity against the HCT-116 human adenocarcinoma cell line with libertellenone D being the most potent (IC50 = 0.76 mu M). (c) 2005 Elsevier Ltd. All rights reserved.