Peripheral blood leukocyte counts in cytomegalovirus infected heart transplant patients: impact of acute disease versus subclinical infection.
Peripheral blood leukocyte counts in cytomegalovirus infected heart transplant patients: impact of acute disease versus subclinical infection.
复制标题
巨细胞病毒感染的心脏移植患者的外周血白细胞计数：急性疾病与亚临床感染的影响。
DOI：
10.1097/01.tp.0000242139.13197.7f
复制
发表时间：
2006
期刊：
影响因子：
6.2
通讯作者：
Valantine,HannahA
中科院分区：
文献类型：
--
作者：
Cooke,MargaretE;Potena,Luciano;Luikart,Helen;Valantine,HannahA
Background.Cytomegalovirus (CMV)-associated leucopenia in heart transplant patients is poorly characterized.Methods.We conducted a retrospective analysis of timing, degree, and type of leukopenia in four groups of patients: cases (n= 20); controls (n= 20); subclinical early infection (n= 21), and subclinical late infection (n= 22). In the cases, white blood cells (WBC) count at diagnosis was compared to prediagnosis; and cases were compared to controls. Subclinical cases (early and late) were identified by measurement of CMV DNA in peripheral blood mononucleocytes, and WBC was compared to those of the cases and controls.Results.First, in human heart transplant recipients the total leukocyte count decreased prior to the time of diagnosis of CMV disease: cases: 5.4±2.1× 10 3/μL vs. 3.7±2.1× 10 3/μL (P< 0.01); subclinical early: 8.1±4.1× 10 3/uL vs. 6.9±1.6× 10 3/uL (P< 0.01). Second, the leukocyte populations most reduced during CMV disease are the neutrophils: 4.4× 10 3/uL (78%) to 2.5× 10 3/uL (69%)(P< 0.05), and monocytes 0.6× 10 3/μL (11%) to 0.3× 10 3/μL (7.5%)(P< 0.05). Third, the reduction in leukocyte count that occurs during CMV disease appears to be independent of immunosuppressive therapy (using cyclosporine A, mycophenolate mofetil, or azathioprine and prednisone). Finally, subclinical CMV infection in stable long-term heart transplant patients without disease is unassociated with a reduction in the leukocyte count.Conclusions.Aside from implications for early diagnosis, CMV-associated decrease in monocytes is important because viral infections like Epstein-Barr virus cause monocytosis. The absence of leucopenia in subclinical late infections is a new important finding.
登录
查看更多内容
肺的细胞外水解酶。
影响因子：
2.9
作者：
G. Hook
通讯作者：
G. Hook
肺表面活性物质系统的代谢和发育方面。
DOI：
10.1016/0304-4157(88)90011-1
发表时间：
1988
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
M. Post;L.M.G. Van Golde
通讯作者：
L.M.G. Van Golde
膜和脂蛋白样品中的蛋白质测定：手动和自动程序。
影响因子：
--
作者：
M. Markwell;S. M. Haas;N. Tolbert;L. Bieber
通讯作者：
L. Bieber
肺板层体维持酸性内部pH值。
DOI：
--
发表时间：
1986
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Chander,A;Johnson,RG;Reicherter,J;Fisher,AB
通讯作者：
Fisher,AB
肺中溶酶体丝氨酸蛋白酶的细胞化学定位和生化评估：正常大鼠中的二肽基肽酶 II。
影响因子：
3.2
作者：
S. Randell;P. Sannes
通讯作者：
P. Sannes