Obesity as a Determinant of Staphylococcus aureus Colonization Among Inmates in Maximum-Security Prisons in New York State
Obesity as a Determinant of Staphylococcus aureus Colonization Among Inmates in Maximum-Security Prisons in New York State
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DOI：
10.1093/aje/kwv062
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发表时间：
2015-09-15
影响因子：
5
通讯作者：
Larson, Elaine L.
中科院分区：
文献类型：
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作者：
Befus, Montina;Lowy, Franklin D.;Larson, Elaine L.
肥胖增加了一个人对各种感染的易感性，包括金黄色葡萄球菌感染，这是惩教场所发病率的一个重要原因。使用横断面设计，我们评估了肥胖和金黄色葡萄球菌定植之间的联系，金黄色葡萄球菌是随后感染的一个风险因素，在纽约州最高安全级别的监狱中(2011-2013年)。收集前鼻孔和口咽部培养物。结构化访谈和医疗记录被用来收集人口统计学、行为和医学数据。体重指数(BMI；体重(公斤)/身高(m(2)被归类为18.5-24.9，25-29.9，30-34.9，或千分之35。采用对数二项式回归分析体重指数与金黄色葡萄球菌定植之间的关系。在638名女性囚犯中，38%的女性囚犯和794名男性囚犯中的26%的人BMI为30或更高。超过40%的囚犯被殖民。在控制了年龄、教育程度、吸烟状况、糖尿病状况和人类免疫缺陷病毒感染后，体重指数25~29.9(患病率PR=1.37，95%可信区间1.06，1.76)、30~34.9(PR=1.52，95%CI：1.17，1.98)或百万分之35(PR=1.49，95%CI：1.13，1.96)的女性囚犯的移居率高于BMI为18.5~24.9的女性囚犯。BMI在30~34.9之间的男性囚犯的移居率较高(PR=1.27，95%CI：1.01，1.61)。我们的发现表明，女性囚犯中的体重指数和金黄色葡萄球菌定植之间存在关联。应探索潜在的生物学和行为因素。
Obesity increases a person's susceptibility to a variety of infections, including Staphylococcus aureus infections, which is an important cause of morbidity in correctional settings. Using a cross-sectional design, we assessed the association between obesity and S. aureus colonization, a risk factor for subsequent infection, in New York State maximum-security prisons (2011-2013). Anterior nares and oropharyngeal cultures were collected. Structured interviews and medical records were used to collect demographic, behavioral, and medical data. Body mass index (BMI; weight (kg)/height (m(2))) was categorized as 18.5-24.9, 25-29.9, 30-34.9, or a parts per thousand yen35. The association between BMI and S. aureus colonization was assessed using log-binomial regression. Thirty-eight percent of 638 female inmates and 26% of 794 male inmates had a BMI of 30 or higher. More than 40% of inmates were colonized. Female inmates with a BMI of 25-29.9 (prevalence ratio (PR) = 1.37, 95% confidence interval (CI): 1.06, 1.76), 30-34.9 (PR = 1.52, 95% CI: 1.17, 1.98), or a parts per thousand yen35 (PR = 1.49, 95% CI: 1.13, 1.96) had a higher likelihood of colonization than did those with a BMI of 18.5-24.9 after we controlled for age, educational level, smoking status, diabetes status, and presence of human immunodeficiency virus. Colonization was higher among male inmates with a BMI of 30-34.9 (PR = 1.27, 95% CI: 1.01, 1.61). Our findings demonstrate an association between BMI and S. aureus colonization among female prisoners. Potential contributory biologic and behavioral factors should be explored.