Enteropathy associated with the acquired immunodeficiency syndrome.
Enteropathy associated with the acquired immunodeficiency syndrome.
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DOI：
10.7326/0003-4819-101-4-421
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发表时间：
1984-10
影响因子：
39.2
通讯作者：
D. Kotler;H. Gaetz;M. Lange;E. Klein;P. Holt
中科院分区：
文献类型：
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作者：
D. Kotler;H. Gaetz;M. Lange;E. Klein;P. Holt
为探讨获得性免疫缺陷综合征对胃肠道结构和吸收的影响，对12例男同性恋者和11例同性恋对照组进行了研究。7例患者出现腹泻并体重减轻。未发现细菌或寄生虫感染。所有患者均营养不良；t淋巴细胞辅助细胞和抑制细胞显著减少；体重、中臂围、血清白蛋白浓度和铁结合能力明显低于同性恋对照组。患者中存在d -木糖吸收不良和脂肪漏，特别是腹泻患者。所有腹泻患者的空肠和直肠活检标本均有组织学异常。空肠异常包括部分绒毛萎缩伴隐窝增生和上皮内淋巴细胞数量增加。直肠异常包括核内病毒包涵体、固有层肥大细胞浸润和隐窝基部附近的局灶性细胞变性。组织学结果表明，在一些患者中，小肠和结肠固有层发生了一种特殊的病理过程。
To explore the effect of the acquired immunodeficiency syndrome on gastrointestinal structure and absorption, the cases of 12 homosexual men with the syndrome and 11 homosexual controls were studied. Seven patients had diarrhea with weight loss. Bacterial or parasitic infections were not detected. All patients were malnourished; had significantly fewer T-lymphocyte helper and suppressor cells; and had significantly lower body weights, midarm circumferences, serum albumin concentrations, and iron binding capacities than homosexual controls. D-Xylose malabsorption and steatorrhea were present in patients, especially those with diarrhea. Jejunal and rectal biopsy samples were histologically abnormal in all patients with diarrhea. Jejunal abnormalities included partial villus atrophy with crypt hyperplasia and increased numbers of intraepithelial lymphocytes. Rectal abnormalities included intranuclear viral inclusions, mast cell infiltration in the lamina propria, and focal cell degeneration near the crypt base. The histologic findings suggest that a specific pathologic process occurs in the lamina propria of the small intestine and colon in some patients with the syndrome.