Pure choriocarcinoma of ovary diagnosed by fine needle aspiration cytology
Pure choriocarcinoma of ovary diagnosed by fine needle aspiration cytology
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DOI：
10.4103/0377-4929.55013
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发表时间：
2009-07-01
影响因子：
1
通讯作者：
Jagtap, S. V.
中科院分区：
文献类型：
--
作者：
Naniwadekar, M. R.;Desai, S. R.;Jagtap, S. V.
纯卵巢绒毛膜癌极为罕见，可发展为生殖细胞肿瘤或子宫或输卵管妊娠绒毛膜癌的转移灶，极少发生于卵巢妊娠。以前在不同部位的细胞形态学发现已被报道过。然而，据我们所知，这是第一例纯卵巢绒毛膜癌的细胞学诊断。区分妊娠期绒毛膜癌和非妊娠期绒毛膜癌是困难的。一位19岁的女性患者表现为不规则阴道出血和下腹肿块。细针吸细胞学检查显示肿块细胞少，可见大的多核巨细胞和恶性的单核细胞。背景是出血。血清hCG水平为380000 mIU/ml。诊断为绒毛膜癌，后经组织病理学证实。绒毛膜癌的细针穿刺细胞学诊断是基于大的，多核巨细胞和恶性单核细胞的存在。应保持高度的怀疑指数，血清hCG的估计在支持诊断中起关键作用。
Pure ovarian choriocarcinoma is extremely rare and can develop as a germ cell tumor or as a metastasis from uterine or tubal gestational choriocarcinoma or rarely from an ovarian pregnancy. The cytomorphologic findings have been reported previously in different sites. However, this is the first case of pure ovarian choriocarcinoma diagnosed on cytology to the best of our knowledge. The distinction between a gestational and nongestational choriocarcinoma is difficult. A 19-year-old female patient presented with an irregular per-vaginal bleeding and a mass in lower abdomen. Fine needle aspiration cytology smears of the mass were hypocellular and showed large, multinucleated giant cells and malignant mononucleated cells. Background was hemorrhagic. Serum hCG level was 3,80,000 mIU/ml. A diagnosis of choriocarcinoma was offered which was later confirmed by histopathology. The diagnosis of choriocarcinoma on fine needle aspiration cytology is based on the presence of large, multinucleated giant cells and malignant mononucleated cells. A high index of suspicion should be maintained and estimation of serum hCG plays a key role in supporting the diagnosis.