Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome
Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome
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DOI：
10.1161/01.cir.0000150391.38660.9b
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发表时间：
2004-12-21
期刊：
影响因子：
37.8
通讯作者：
Laakso, M
中科院分区：
文献类型：
--
作者：
Salmenniemi, U;Ruotsalainen, E;Laakso, M
背景-葡萄糖和能量代谢的详细代谢缺陷和各种心血管危险因素的异常在很大程度上是未知的主题与metabolic syndrome.Methods和Results-We的特点代谢综合征在119个非糖尿病后代的糖尿病先证者。测量心血管危险因素，包括细胞因子和粘附分子。胰岛素敏感性通过正常血糖高胰岛素钳夹和间接热量测定法进行评估;腹内脂肪和皮下脂肪通过CT进行评估;最大耗氧量通过自行车测力计测试进行测量。通过应用因子分析，我们从以下变量中确定了一个单一的因子，即代谢综合征因子：2小时血糖、空腹胰岛素、体重指数、腰围、HDL胆固醇、甘油三酯和平均血压。具有最高因子得分的受试者被定义为患有代谢综合征。在高胰岛素血症期间，最高因子评分与高胰岛素血症期间葡萄糖氧化和非氧化葡萄糖处置率降低、脂质氧化率高、能量消耗低和游离脂肪酸抑制受损相关。此外，代谢综合征与大量内脏脂肪、低脂联素血症、最大摄氧量低、C反应蛋白、促炎细胞因子和粘附分子水平高有关。结论：代谢综合征的特征是腹内脂肪过多、低脂联素血症、骨骼肌和脂肪组织的胰岛素抵抗、葡萄糖和能量代谢的多重缺陷，以及细胞因子和粘附分子水平升高。
Background-Detailed metabolic defects in glucose and energy metabolism and abnormalities in a variety of cardiovascular risk factors are largely unknown in subjects with the metabolic syndrome.Methods and Results-We characterized the metabolic syndrome in 119 nondiabetic offspring of diabetic probands. Cardiovascular risk factors, including cytokines and adhesion molecules, were measured. Insulin sensitivity was assessed by the euglycemic hyperinsulinemic clamp and indirect calorimetry; intra-abdominal fat and subcutaneous fat were assessed by CT; and maximal oxygen consumption was measured with a bicycle ergometer test. By applying factor analysis, we identified a single factor, the metabolic syndrome factor, from the following variables: 2-hour glucose, fasting insulin, body mass index, waist, HDL cholesterol, triglycerides, and mean blood pressure. Subjects with the highest factor score were defined as having the metabolic syndrome. During hyperinsulinemia, the highest factor score was associated with decreased rates of glucose oxidation and nonoxidative glucose disposal, high rates of lipid oxidation, low energy expenditure, and impaired suppression of free fatty acids during hyperinsulinemia. Furthermore, the metabolic syndrome was associated with a high amount of visceral fat, hypoadiponectinemia, a low maximum oxygen uptake, and high levels of C-reactive protein, proinflammatory cytokines, and adhesion molecules.Conclusions-The metabolic syndrome is characterized by an excess of intra-abdominal fat, hypoadiponectinemia, insulin resistance in skeletal muscle and adipose tissue, multiple defects in glucose and energy metabolism, and elevated levels of cytokines and adhesion molecules.