Gene-environment interaction in vulnerability to schizophrenia: findings from the Finnish Adoptive Family Study of Schizophrenia.
Gene-environment interaction in vulnerability to schizophrenia: findings from the Finnish Adoptive Family Study of Schizophrenia.
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基因与环境的相互作用导致精神分裂症的易感性：芬兰收养家庭精神分裂症研究的结果。
DOI：
10.1176/ajp.154.3.355
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Tienari,P
中科院分区：
文献类型：
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作者：
Wahlberg,KE;Wynne,LC;Oja,H;Keskitalo,P;Pykalainen,L;Lahti,I;Moring,J;Naarala,M;Sorri,A;Seitamaa,M;Laksy,K;Kolassa,J;Tienari,P
本研究评估的相互作用的遗传风险和抚养家庭的风险作为一个亚综合征的精神分裂症的思维障碍的测试措施adoptees.MethodA组的58名精神分裂症的亲生母亲被收养人进行了比较，96个比较收养人在普通的遗传风险;推定的收养人的脆弱性进行了评估盲目和可靠的原始思想的罗夏指数。环境风险的测量使用频率的通信偏差作为一个连续变量，评分独立于罗夏评估的养父母。ResultsHigh遗传风险本身并不与更大的脆弱性精神分裂症的思想障碍的被收养者，所示的原始思想的指数。此外，养父母更大的沟通偏差与被收养者的思维障碍无关。然而，有一个非常显着的基因-环境相互作用。在具有高水平沟通异常的养父母的后代中，高风险被收养者的比例高于对照被收养者，显示出思维障碍的证据。相比之下，在低沟通偏差的养父母的后代中，高风险的比例低于对照被收养者，显示出思维障碍的证据。通信偏差分数的分布并没有显着差异的养父母之间的高风险的后代和养父母的comparationchildren.ConclusionsThe研究结果是一致的遗传控制的敏感性的环境。没有证据表明后代患精神分裂症的高遗传风险与养育父母的高水平沟通问题有关。
ObjectiveThis study assessed the interaction of genetic risk and rearing-family risk as a subsyndromal test measure of schizophrenic thought disorder in adoptees.MethodA group of 58 adoptees with schizophrenic biological mothers was compared with 96 comparison adoptees at ordinary genetic risk; putative adoptee vulnerability was assessed blindly and reliably by using the Rorschach Index of Primitive Thought. Environmental risk was measured by using frequency of communication deviance as a continuous variable, scored independently from Rorschach assessments of the adoptive parents.ResultsHigh genetic risk in itself was not associated with greater vulnerability to schizophrenic thought disorder in the adoptees, as indicated by the Index of Primitive Thought. Also, greater communication deviance in the adoptive parents was not associated with greater thought disorder in the comparison adoptees. However, there was a highly significant gene-environment interaction. Among the offspring of the adoptive parents with high levels of communication deviance, a higher proportion of high-risk than comparison adoptees showed evidence of thought disorder. In contrast, among the offspring of adoptive parents with low communication deviance, a lower proportion of high-risk than comparison adoptees showed evidence of thought disorder. The distribution of communication deviance scores did not differ significantly between the adoptive parents of high-risk offspring and the adoptive parents of comparison offspring.ConclusionsThe findings are consistent with genetic control of sensitivity to the environment. There is no evidence that high genetic risk of schizophrenia among offspring is associated with high levels of communication problems in rearing parents.