Beneficial cardiovascular pleiotropic effects of statins
Beneficial cardiovascular pleiotropic effects of statins
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DOI：
10.1161/01.cir.0000131517.20177.5a
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发表时间：
2004-06-15
期刊：
影响因子：
37.8
通讯作者：
Davignon, J
中科院分区：
文献类型：
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作者：
Davignon, J
药物的多效性作用是指除药物专门开发的作用之外的作用。这些效应可能与药物的主要作用机制有关或无关，通常是意料之外的。多效性作用可能是不希望的（如副作用或毒性）、中性的，或者特别是HMG-CoA还原酶抑制剂（他汀类药物）的情况下是有益的。他汀类药物的多效性作用包括改善内皮功能障碍、增加一氧化氮生物利用度、抗氧化特性、抑制炎症反应和稳定动脉粥样硬化斑块。这些和其他几个新出现的特性可以与他汀类药物有效的低密度脂蛋白胆固醇降低作用协同作用，以发挥早期和持久的心血管保护作用。了解他汀类药物的多效性作用对于优化其在心血管疾病治疗和预防中的应用非常重要。
Pleiotropic effects of a drug are actions other than those for which the agent was specifically developed. These effects may be related or unrelated to the primary mechanism of action of the drug, and they are usually unanticipated. Pleiotropic effects may be undesirable (such as side effects or toxicity), neutral, or, as is especially the case with HMG-CoA reductase inhibitors (statins), beneficial. Pleiotropic effects of statins include improvement of endothelial dysfunction, increased nitric oxide bioavailability, antioxidant properties, inhibition of inflammatory responses, and stabilization of atherosclerotic plaques. These and several other emergent properties could act in concert with the potent low-density lipoprotein cholesterol -lowering effects of statins to exert early as well as lasting cardiovascular protective effects. Understanding the pleiotropic effects of statins is important to optimize their use in treatment and prevention of cardiovascular disease.