Evaluation of the use of non-invasive hemoglobin measurement in early childhood
Evaluation of the use of non-invasive hemoglobin measurement in early childhood
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DOI：
10.1038/s41390-022-02204-7
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发表时间：
2022-07-29
影响因子：
3.6
通讯作者：
Shimizu, Toshiaki
中科院分区：
文献类型：
--
作者：
Arai, Yoshiteru;Shoji, Hiromichi;Shimizu, Toshiaki
研究背景儿童缺铁性贫血影响智力发育。我们比较了彩虹脉冲一氧化碳血氧饱和度技术的动脉血红蛋白（Hb）浓度（SpHb）的非侵入性经皮分光光度估计的准确性和趋势的侵入性血液Hb浓度测量的自动临床分析仪（Hb-Lab）。方法对109例1-5岁儿童进行SpHb和Hb-Lab测定。回归分析用于评估两种方法之间的差异。使用Bland-Altman方法计算SpHb与Hb-Lab相比的偏倚、准确度、精密度和一致性限。结果在109例受试者中，共收集到102对SpHb和Hb-Lab数据集。Hb-Lab测得的Hb平均值为12.9 +/- 1.03（标准差[SD]）g/dL。SpHb与Hb-Lab测量值之间观察到显著相关（SpHb = 7.002 + 0.4722 Hb-Lab，相关系数r = 0.548，95%置信区间= 0.329-0.615）。Bland-Altman分析显示目视一致性良好，SpHb和Hb-Lab之间的平均偏倚为0.188 +/- 0.919 g/dL（平均值+/- SD）。结论：无创性Hb测量对儿童Hb的估计是有用的，并作为贫血的筛查工具提供了新的见解。影响我们的研究结果表明，非侵入性经皮分光光度法估计动脉血红蛋白（Hb）浓度，使用手指探头传感器的彩虹脉冲CO-血氧饱和度技术和侵入性血液Hb浓度之间的相关性良好。虽然以前的研究表明，在病情较重的患者中，两种方法之间的偏倚较大，但这项研究是在病情稳定的儿童中进行的，显示出相对较小的偏倚。使用这种非侵入性设备的进一步研究可能有助于了解日本贫血的现状，并促进儿童的铁摄入和营养管理。
Background Iron deficiency anemia in children affects psychomotor development. We compared the accuracy and trend of a non-invasive transcutaneous spectrophotometric estimation of arterial hemoglobin (Hb) concentration (SpHb) by rainbow pulse CO-oximetry technology to the invasive blood Hb concentration measured by an automated clinical analyzer (Hb-Lab). Methods We measured the SpHb and Hb-Lab in 109 patients aged 1-5 years. Regression analysis was used to evaluate differences between the two methods. The bias, accuracy, precision, and limits of agreement of SpHb compared with Hb-Lab were calculated using the Bland-Altman method. Results Of the 109 enrolled subjects, 102 pairs of the SpHb and Hb-Lab datasets were collected. The average value of measured Hb was 12.9 +/- 1.03 (standard deviation [SD]) g/dL for Hb-Lab. A significant correlation was observed between SpHb and Hb-Lab measurements (SpHb = 7.002 + 0.4722 Hb-Lab, correlation coefficient r = 0.548, 95% confidence interval = 0.329-0.615). Bland-Altman analysis showed good visual agreement, with a mean bias between SpHb and Hb-Lab of 0.188 +/- 0.919 g/dL (mean +/- SD). Conclusions We concluded that non-invasive Hb measurement is useful for Hb estimation in children and provides new insights as a screening tool for anemia. Impact Our results indicated a good correlation between non-invasive transcutaneous spectrophotometric estimation of arterial hemoglobin (Hb) concentration using a finger probe sensor by rainbow pulse CO-oximetry technology and invasive blood Hb concentration. Although previous studies have indicated that in patients with a worse condition, the bias between the two methods was large, this study, which was conducted on children with stable disease, showed a relatively small bias. Further studies using this non-invasive device might help to understand the current status of anemia in Japan and promote iron intake and nutritional management in children.