The association between circulating 25-hydroxyvitamin D and cardiovascular diseases: a meta-analysis of prospective cohort studies
The association between circulating 25-hydroxyvitamin D and cardiovascular diseases: a meta-analysis of prospective cohort studies
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DOI：
10.1186/s12872-019-1236-7
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发表时间：
2019-11-07
影响因子：
2.1
通讯作者：
Ghaderi, Ebrahim
中科院分区：
文献类型：
--
作者：
Gholami, Fatemeh;Moradi, Ghobad;Ghaderi, Ebrahim
背景维生素D与心血管疾病（cvd）之间的关系存在争议。评价血清25-OH-vitD水平对心血管疾病发生风险的影响。方法检索Scopus、Science Direct、PubMed等主要电子数据库。2000年4月至2017年9月期间进行的所有关于维生素D状态与心血管疾病之间关系的前瞻性队列研究均被纳入，无论使用何种语言。研究人员不分年龄、性别和种族对参与者进行了评估。纽卡斯尔-渥太华量表用于评估研究的质量。两位研究者独立选择研究并提取数据。指定效应为风险比（RR）和风险比（HR）。采用随机效应模型对结果进行组合。结果对25项研究10,099例cvd进行了荟萃分析。一般来说，维生素D水平的降低与心血管疾病（发病率-死亡率）的相对风险较高相关（RR = 1.44, 95% CI: 1.24-1.69）。这占心血管疾病死亡率的54% （RR = 1.54, 95% CI: 1.29-1.84）。然而，维生素D水平与心血管疾病发病率之间没有显著关系（RR = 1.18, 95% CI: 1-1.39）。总的来说，低血清维生素D水平使心血管疾病的风险增加44% （RR = 1.44, 95% CI: 1.24-1.69）。它还增加了心血管疾病死亡率（RR = 1.54, 95% CI: 1.29-1.84）和发病率（RR = 1.18, 95% CI: 1-1.39）。结论维生素D缺乏会增加心血管疾病的死亡率。由于对男女患者的研究数量有限，建议进一步研究分别评估维生素D水平对男性和女性CVD的影响。
Background There is a controversy about the association between vitamin D and cardiovascular diseases (CVDs). The effect of serum 25-OH-vitD on the risk of CVDs was evaluated. Methods Major electronic databases including Scopus, Science Direct, and PubMed were searched. All prospective cohort studies on the relationship between vitamin D status and CVDs conducted between April 2000 and September 2017 were included, regardless language. The study participants were evaluated regardless of their age, sex, and ethnicity. The Newcastle-Ottawa Scale was used to assess the quality of the studies. Two investigators independently selected the studies and extracted the data. The designated effects were risk ratio (RR) and hazard ratio (HR). The random effects model was used to combine the results. Results A meta-analysis of 25 studies with 10,099 cases of CVDs was performed. In general, a decrease in the level of vitamin D was associated with a higher relative risk of CVDs (incidence-mortality combined) (RR = 1.44, 95% CI: 1.24-1.69). This accounts for 54% of CVDs mortality rate (RR = 1.54, 95% CI: 1.29-1.84(. However, no significant relationship was observed between the vitamin D status and incidence of CVDs (RR = 1.18, 95% CI: 1-1.39). In general, low serum vitamin D level increased the risk of CVD by 44% (RR = 1.44, 95% CI: 1.24-1.69). It also increased the risk of CVD mortality (RR = 1.54, 95% CI: 1.29-1.84) and incidence rates (RR = 1.18, 95% CI: 1-1.39). Conclusions The findings showed that vitamin D deficiency increases the CVDs mortality rate. Due to the limited number of studies on patients of the both genders, further research is suggested to separately evaluate the effect of vitamin D status on CVD in men and women.