Type 1 diabetes as a relapsing-remitting disease?
Type 1 diabetes as a relapsing-remitting disease?
复制标题
DOI：
10.1038/nri2192
复制
发表时间：
2007-12-01
影响因子：
100.3
通讯作者：
Herold, Kevan
中科院分区：
文献类型：
--
作者：
von Herrath, Matthias;Sanda, Srinath;Herold, Kevan
慢性免疫过程是持续性病毒感染和自身免疫性疾病（如多发性硬化症）的基础，在本质上可能是复发缓解型的。在自身免疫性1型糖尿病（T1 D）的发展过程中，β-细胞质量的进行性损失也可以是非线性的，但支配T1 D的免疫过程的确切性质和动力学尚不清楚。在这里，我们提出，免疫过程是T1 D的根源是复发缓解的性质，并讨论了这一假设的未解决的争议和治疗意义。
Chronic immunological processes that underlie persistent viral infections and autoimmune disorders such as multiple sclerosis can be relapsing - remitting in nature. The progressive loss of beta-cell mass during the development of autoimmune type 1 diabetes ( T1D) can also be non - linear, but the exact nature and kinetics of the immunological processes that govern T1D are not known. Here, we propose that the immunological process that is at the root of T1D is relapsing remitting in nature and discuss the unresolved controversies and therapeutic implications of this hypothesis.