Chitosan based hydrogels: characteristics and pharmaceutical applications
Chitosan based hydrogels: characteristics and pharmaceutical applications
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DOI：
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发表时间：
2015-01
影响因子：
2.1
通讯作者：
F. Ahmadi;Z. Oveisi;S. Samani;Zohreh Amoozgar
中科院分区：
文献类型：
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作者：
F. Ahmadi;Z. Oveisi;S. Samani;Zohreh Amoozgar
水凝胶支架用作半合成或合成的细胞外基质，以在模拟天然细胞环境的三维结构中为细胞粘附和细胞重塑提供顺从的环境。此外，水凝胶具有携带小分子药物和/或蛋白质、生长因子和细胞生长和分化的其他必要组分的能力。在药物递送的背景下，水凝胶可用于定位药物，增加作用部位的药物浓度，从而减少脱靶副作用。本文综述了水凝胶及其生产方法的研究进展。主要亮点是壳聚糖基水凝胶作为生物相容性和医学相关的水凝胶用于药物递送。
Hydrogel scaffolds serve as semi synthetic or synthetic extra cellular matrix to provide an amenable environment for cellular adherence and cellular remodeling in three dimensional structures mimicking that of natural cellular environment. Additionally, hydrogels have the capacity to carry small molecule drugs and/or proteins, growth factors and other necessary components for cell growth and differentiation. In the context of drug delivery, hydrogels can be utilized to localize drugs, increase drugs concentration at the site of action and consequently reduce off-targeted side effects. The current review aims to describe and classify hydrogels and their methods of production. The main highlight is chitosan-based hydrogels as biocompatible and medically relevant hydrogels for drug delivery.