Rapid microwave-assisted solid-phase glycopeptide synthesis
Rapid microwave-assisted solid-phase glycopeptide synthesis
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DOI：
10.1021/ol0474352
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发表时间：
2005-03-03
期刊：
影响因子：
5.2
通讯作者：
Nishimura, SI
中科院分区：
文献类型：
--
作者：
Matsushita, T;Hinou, H;Nishimura, SI
Coupling of glycosylated Fmoc-Thr or Fmoc-Ser with N-terminal amino acids on a resin proceeded smoothly under microwave irradiation for 20 min with much higher efficiency (98% yield per coupling) than found in more general conditions. Compared with a conventional protocol, the present method greatly reduces the time required for solid-phase glycopeptide synthesis from 4 days to 7 h, as is the case with the synthesis of Muc-1-related 20-residue glycopeptide carrying five core-2 trisaccharide chains.
