HYPOTHALAMIC CONTROL OF FEEDING AND SELF-STIMULATION
HYPOTHALAMIC CONTROL OF FEEDING AND SELF-STIMULATION
复制标题
DOI：
10.1126/science.135.3501.375
复制
发表时间：
1962-01-01
期刊：
影响因子：
56.9
通讯作者：
TEITELBAUM, P
中科院分区：
文献类型：
--
作者：
HOEBEL, BG;TEITELBAUM, P
控制进食的下丘脑部位对外侧下丘脑自我刺激施加相应的控制。这在带有四个用于电刺激或化学注射的下丘脑内电极套管的大鼠中得到证实。下丘脑外侧的自我刺激被腹内侧兴奋或过度喂养所抑制。腹内侧消融或麻醉可加速（解除抑制）自我刺激和进食。因此，食物通过腹内侧下丘脑不仅抑制进食，而且抑制外侧下丘脑的自我刺激。
Hypothalamic sites which control feeding exert a corresponding control over lateral hypothalamic self-stimulation. This was demonstrated in rats bearing four, intrahypothalamic electrode-cannulas for electrical stimulation or chemical injection. Self-stimulation of the lateral hypothalamus was inhibited by ventromedial excitation or by excessive feeding. Both self-stimulation and feeding were accelerated (disinhibited) by ventromedial ablation or anesthetization. Thus food acts via the ventromedial hypothalamus to inhibit not only feeding, but also lateral hypothalamic self-stimulation.