Duodenal follicular lymphomas share common characteristics with mucosa-associated lymphoid tissue lymphomas
Duodenal follicular lymphomas share common characteristics with mucosa-associated lymphoid tissue lymphomas
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DOI：
10.1136/jcp.2007.049825
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发表时间：
2008-03-01
影响因子：
3.4
通讯作者：
Yoshino, T.
中科院分区：
文献类型：
--
作者：
Sato, Y.;Ichimura, K.;Yoshino, T.
背景：滤泡性淋巴瘤偶尔发生在结外器官，常见于十二指肠。目的：检测IgH/bcl2杂合基因和VH基因，探讨淋巴瘤细胞的性质及其与结节性滤泡性淋巴瘤和MALT淋巴瘤的区别。方法：对已报道的40例十二指肠滤泡性淋巴瘤中的35例进行了详细的临床病理分析。53.3%的病例检测到克隆性免疫球蛋白基因重排，27%的病例检测到主要断裂点的IgH/bcl2基因重排。8例确诊病例中有3例为VH4(38%)，其中2例为VH4-34。由于VH4偏移是MALT淋巴瘤的共同特征之一，且2/3相同，因此十二指肠滤泡性淋巴瘤的病因与MALT淋巴瘤相似。临床病程与MALT淋巴瘤相似。结论：十二指肠滤泡性淋巴瘤具有MALT淋巴瘤和结节性滤泡性淋巴瘤的中间特征。
Background: Follicular lymphomas occasionally arise in the extra-nodal organs and are frequently found in the duodenum. They are often localised tumours with multiple polyps around the ampulla of Vater.Aims: To examine a IgH/bcl-2 hybrid gene and VH gene to investigate the nature of the lymphoma cells and how they differ from nodal follicular lymphomas and MALT lymphomas.Methods: Of 40 patients reported previously, 35 with duodenal follicular lymphoma were studied in detail with respect to clinicopathological characteristics.Results: 37/40 patients were in clinical stage I (n= 30) or stage II (n= 7). Clonal immunoglobulin gene rearrangement was detected in 53.3% of examined cases, and rearrangement of IgH/bcl-2 gene at the major break point was detected in 27% of cases. Three of 8 examined cases were VH4 (38%); 2 out of them were VH4-34. As VH4 deviation is one of the common characteristics of MALT lymphomas and 2/3 were identical, duodenal follicular lymphomas have a similar aetiology to MALT lymphomas. Clinical course was also similar to that of MALT lymphomas.Conclusions: Results suggest that duodenal follicular lymphomas have intermediate characteristics of MALT lymphomas and nodal follicular lymphomas.