Mitochondrial metabolites: undercover signalling molecules.
Mitochondrial metabolites: undercover signalling molecules.
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DOI：
10.1098/rsfs.2016.0100
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发表时间：
2017-04-06
期刊：
影响因子：
4.4
通讯作者：
Frezza C
中科院分区：
文献类型：
--
作者：
Frezza C
线粒体是细胞中最具特征的代谢中心之一。在这里，发生关键的生化反应，并产生大部分细胞三磷酸腺苷（ATP）。此外，线粒体还充当信号平台，通过调节钙通量、产生自由基和释放生物活性蛋白质来与细胞的其他部分进行交流。线粒体代谢物也可以作为第二信使，并可以引起深刻的（epi）遗传变化。本文综述了在正常和应激条件下线粒体代谢物的许多信号功能，重点是三羧酸循环的代谢物。我们为理解线粒体代谢在细胞病理生理学中的作用提供了一个新的框架。
Mitochondria are one of most characterized metabolic hubs of the cell. Here, crucial biochemical reactions occur and most of the cellular adenosine triphosphate (ATP) is produced. In addition, mitochondria act as signalling platforms and communicate with the rest of the cell by modulating calcium fluxes, by producing free radicals, and by releasing bioactive proteins. It is emerging that mitochondrial metabolites can also act as second messengers and can elicit profound (epi)genetic changes. This review describes the many signalling functions of mitochondrial metabolites under normal and stress conditions, focusing on metabolites of the tricarboxylic acid cycle. We provide a new framework for understanding the role of mitochondrial metabolism in cellular pathophysiology.