Effect of mycobacterial infection on virus loads and disease progression in simian immunodeficiency virus-infected rhesus monkeys
Effect of mycobacterial infection on virus loads and disease progression in simian immunodeficiency virus-infected rhesus monkeys
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DOI：
10.1089/08892220050195856
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发表时间：
2000-11-01
影响因子：
1.5
通讯作者：
Flynn, JL
中科院分区：
文献类型：
--
作者：
Croix, DA;Capuano, S;Flynn, JL
在猿猴模型中研究了分枝杆菌感染对艾滋病疾病的影响。猴子被初级毒力分离株 SIV/DeltaB670 感染，并在 90 天后接种 BCG（牛分枝杆菌的减毒菌株）。接种卡介苗后，所有猴子的血浆病毒血症和 T 淋巴细胞上的 CCR5 表达均出现短暂的急剧增加。四只 SIV+ 动物中只有两只对 PPD 具有显着的增殖反应，反应较差的动物在实验过程中出现了播散性 BCG。还对感染 SIV 的长期无进展 (LTNP) 猴进行了 BCG 接种。与急性感染的动物类似，三分之二的 LTNP 血浆病毒水平和 CCR5 表达增加。在大多数研究的动物中，尽管病毒复制和 T 淋巴细胞上的 CCR5 表达同时受到短暂刺激，但并没有加速发展为 AIDS。
The effect of a mycobacterial infection on AIDS disease was studied in the simian model. Monkeys were infected with the primary virulent isolate SIV/DeltaB670 and inoculated 90 days later with BCG, an attenuated strain of Mycobacterium bovis. All monkeys experienced a dramatic transient increase in plasma viremia and CCR5 expression on T lymphocytes after BCG inoculation. Only two of the four SIV+ animals had substantial proliferative responses to PPD, with poor responders developing disseminated BCG during the course of the experiment. BCG inoculation of SIV-infected long-term nonprogressor (LTNP) monkeys was also performed. Similar to the acutely infected animals, two of three LTNPs experienced increases in plasma viral levels and CCR5 expression. In the majority of animals studied, there was no accelerated progression to AIDS despite the concomitant transient stimulation of virus replication and CCR5 expression on T lymphocytes.