Renal function, plasma renin, and spontaneous diuresis in an advanced stage of hypertension in rats.
Renal function, plasma renin, and spontaneous diuresis in an advanced stage of hypertension in rats.
复制标题
高血压晚期大鼠的肾功能、血浆肾素和自发利尿。
DOI：
10.1536/ihj.21.737
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Y. Yamori
中科院分区：
文献类型：
--
作者：
M. Matsunaga;T. Komuro;J. Yamamoto;A. Hara;K. Morimoto;Y. Yamori
在易发生中风的自发性高血压大鼠（SHRSP）中检查了肾功能和血浆肾素水平与高血压晚期自发性利尿的关系。为了进行比较，还在肾血管性高血压大鼠的2肾1夹（1CR）和2肾2夹（2CR）模型中进行了研究。 SHRSP 和 1CR 中自发性利尿通常与血浆肾素水平升高和肾功能损害有关。在 SHRSP 中，肾血浆流量与血浆肾素水平呈负相关。然而，利尿并不是血浆肾素增加或肾损伤的先决条件，因为后者的变化并不总是伴随着利尿。 2CR 中未发现这些因素之间存在相关性。在许多肾功能正常的 2CR 和 2 SHRSP 中观察到了缓泻性利尿，这表明肾损伤是大多数 SHRSP 和 1CR 病例中观察到的利尿持续进展的基础。在利尿期，1CR 和 2CR 中钠和钾平衡均趋于负平衡，而仅钾在 SHRSP 中显示出这种趋势。负平衡（如果有的话）并不是由于电解质的过度损失，而是主要归因于摄入量的减少。自发性利尿的临界血压水平在 SHRSP 中最高，在 1CR 中最低。高血压、肾功能受损和高血浆肾素之间的相互作用和协同作用可能参与了大鼠高血压恶性期发展过程中自发性利尿的机制。
Relationship of renal function and plasma renin level to a spontaneous diuresis in an advanced stage of hypertension was examined in the stroke-prone spontaneously hypertensive rats (SHRSP). For a comparison, it was also investigated in 2 kidney 1 clip (1CR) and 2 kidney 2 clip (2CR) models of renovascular hypertensive rats. The spontaneous diuresis was usually associated with an elevation of plasma renin level and an impairment of renal function in SHRSP and 1CR. In SHRSP, renal plasma flow showed an inverse correlation to the plasma renin level. The diuresis, however, is not prerequisite to the increase in plasma renin or to the renal impairment, since the latter changes were not always accompanied by diuresis. No correlations were found between these factors in 2CR. Remittent diuresis was observed in many 2CRs and 2 SHRSPs with normal renal function, indicating that renal damage underlies the continuous progression of the diuresis observed in most cases of SHRSP and 1CR. Both sodium and potassium balances tended to be negative in 1CR and 2CR in the diuretic phase, whereas potassium alone showed this tendency in SHRSP. The negative balances, if any, were not due to an excessive loss of the electrolytes but attributed mainly to a decrease in intake. The critical level of blood pressure for the spontaneous diuresis was highest in SHRSP and lowest in 1CR. It is probable that an interaction and cooperation between high blood pressure, impaired renal function and high plasma renin participate in the mechanism of the spontaneous diuresis during the development of malignant phase of hypertension of the rat.