Mechanism of transmitter release: voltage hypothesis and calcium hypothesis.
Mechanism of transmitter release: voltage hypothesis and calcium hypothesis.
复制标题
递质释放机制：电压假说和钙假说。
DOI：
10.1126/science.2868525
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Landò,L
中科院分区：
文献类型：
--
作者：
Zucker,RS;Landò,L
突触传递的钙假说受到了使用小龙虾神经肌肉接头的实验结果的挑战，这些实验结果表明，突触前去极化可以直接触发递质释放，而不是钙内流。使用相同制剂的电生理实验结果不支持这一电压假说，但与钙假说一致。电压可以调节发射机的释放，但不能引起发射机的释放。
The calcium hypothesis of synaptic transmission has been challenged by experimental results using the crayfish neuromuscular junction that suggest that presynaptic depolarization can trigger transmitter release directly without calcium influx. Results from electrophysiological experiments using the same preparation do not support this voltage hypothesis, but are consistent with the calcium hypothesis. Voltage may modulate, but not elicit, transmitter release.