Quantification of regional myocardial blood flow estimation with three-dimensional dynamic rubidium-82 PET and modified spillover correction model
Quantification of regional myocardial blood flow estimation with three-dimensional dynamic rubidium-82 PET and modified spillover correction model
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DOI：
10.1007/s12350-012-9558-1
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发表时间：
2012-08-01
影响因子：
2.4
通讯作者：
Tamaki, Nagara
中科院分区：
文献类型：
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作者：
Katoh, Chietsugu;Yoshinaga, Keiichiro;Tamaki, Nagara
用（82）铷（Rb-82）正电子发射断层扫描（PET）估计心肌血流量（MBF）在技术上是困难的，因为感兴趣区域之间的高溢出，特别是由于长的正电子范围。我们试图开发一种新的算法，以减少溢出的图像衍生的血液活动currents.14名志愿者进行了成像与三维（3D）Rb-82和O-15-water PET在休息和药理学应激。使用一室模型估计整个左心室（LV）Rb-82 MBF，包括心肌-血液溢出校正以估计相应的血液输入函数Ca（t）（整体）。区域K1值的计算使用这个统一的全球输入函数，简化了方程，使MBF的鲁棒估计。为了评估改进算法的稳健性，将3D Rb-82 MBF的操作者间重复性与先前建立的方法进行了比较。使用改进的溢出校正方法，Rb-82 MBF与O-15-水MBF的全LV相关性更好（P <0.01）（r = 0.92 vs r = 0.60）。与已建立的方法（r = 0.82）相比，改进的方法还显著提高了局部MBF定量的操作者间重复性（r = 0.89）（P <0.01）。统一的全局输入函数可以抑制LV溢出到图像衍生的血液输入函数中，从而提高了3D Rb-82 PET MBF定量的精度。
Myocardial blood flow (MBF) estimation with (82)Rubidium (Rb-82) positron emission tomography (PET) is technically difficult because of the high spillover between regions of interest, especially due to the long positron range. We sought to develop a new algorithm to reduce the spillover in image-derived blood activity curves, using non-uniform weighted least-squares fitting.Fourteen volunteers underwent imaging with both 3-dimensional (3D) Rb-82 and O-15-water PET at rest and during pharmacological stress. Whole left ventricular (LV) Rb-82 MBF was estimated using a one-compartment model, including a myocardium-to-blood spillover correction to estimate the corresponding blood input function Ca(t)(whole). Regional K1 values were calculated using this uniform global input function, which simplifies equations and enables robust estimation of MBF. To assess the robustness of the modified algorithm, inter-operator repeatability of 3D Rb-82 MBF was compared with a previously established method.Whole LV correlation of Rb-82 MBF with O-15-water MBF was better (P < .01) with the modified spillover correction method (r = 0.92 vs r = 0.60). The modified method also yielded significantly improved inter-operator repeatability of regional MBF quantification (r = 0.89) versus the established method (r = 0.82) (P < .01).A uniform global input function can suppress LV spillover into the image-derived blood input function, resulting in improved precision for MBF quantification with 3D Rb-82 PET.