Light microscopy and magnetic resonance characterization of a DMSA-coated magnetic fluid in mice
Light microscopy and magnetic resonance characterization of a DMSA-coated magnetic fluid in mice
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DOI：
10.1109/tmag.2002.802495
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发表时间：
2002-09-01
影响因子：
2.1
通讯作者：
Azevedo, RB
中科院分区：
文献类型：
--
作者：
Chaves, SB;Lacava, LM;Azevedo, RB
本文采用光学显微镜和磁共振技术研究了二巯基丁二酸磁性纳米粒在小鼠体内的生物分布。形态学分析显示，大量的磁性纳米粒子（MNP）在肺注射后30分钟。与肺相反，形态学分析显示肝脏中MNP的浓度较低。在静脉注射后30 min至4 h，观察到肺和肝中的MNP进行性减少。使用形态学分析，在任何其他器官中均未观察到MNP。为了支持LM观察结果，早在注射后5分钟就在肺和肝中检测到MR信号。此外，早在注射单次剂量后5分钟，在血流中未观察到MR信号。
In this paper, light microscopy and magnetic resonance were used to investigate the biodistribution of magnetite nanoparticles coated with dimercaptosuccinic acid, after intravenous injection of a single dose in mice. Morphological analysis showed a huge amount of magnetic nanoparticles (MNPs) in the lung 30 min after injection. In contrast to the lung, morphological analysis revealed lower concentration of MNPs in the liver. A progressive decrease of MNPs in both lung and liver was observed from 30 min to 4 hours after intravenous injection. MNPs were not observed in any other organs using morphological analysis. In support to the LM observations MR signals were detected in both lung and liver as early as 5 min after injection. In addition, no MR signal was observed in the blood stream as early as 5 min after injection of the single dose.