ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;: 21)(q25-26;: q22)
ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;: 21)(q25-26;: q22)
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DOI：
10.1016/j.leukres.2005.10.014
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发表时间：
2006-08-01
影响因子：
2.7
通讯作者：
Dal Cin, Paola
中科院分区：
文献类型：
--
作者：
Moore, Steven D. P.;Offor, Onyinye;Dal Cin, Paola
我们在AML中报道了一个新的染色体易位，t(X;21)(q25-26;q22)，导致两个ETS结构域家族成员ELF4 （Xq25）和ERG （21 q22）之间的融合转录物。ERG先前与其他融合伙伴相关，特别是FUS和EWSR1，并与AML和Ewing肉瘤有关。从患者骨髓样本中分离的RNA的RT-PCR分析表明，易位发生在ERG异构体1 （erg1）的内含子1和ELF4的内含子2内，导致ELF4的外显子2与ERG的外显子2在框架内融合。这是首次报道ELF4-ERG融合的病例，并鉴定了参与区分ERG异构体融合的特定ERG外显子。此外，该病例也直接暗示了ELF4在癌症中的新作用。(c) 2005 Elsevier Ltd版权所有。
We report a novel chromosomal translocation in AML, t(X;21)(q25-26;q22), resulting in a fusion transcript between two ETS domain family members, ELF4 (at Xq25) and ERG (at 2 1 q22). ERG has been associated previously with other fusion partners, specifically FUS and EWSR1, and implicated in both AML and Ewing's sarcoma. RT-PCR analysis of RNA isolated from bone marrow samples from the patient demonstrates that the translocation occurs within intron 1 of ERG isoform, 1 (ERG-1) and intron 2 of ELF4 resulting in an in-frame fusion joining exon 2 from ELF4 with exon 2 of ERG. This is the first reported case of an ELF4-ERG fusion and identification of the specific ERG exon involved in the fusion that differentiates ERG isoforms. In addition, this case also directly implicates a new role for ELF4 in cancer. (c) 2005 Elsevier Ltd. All rights reserved.