Urinary and plasma levels of vasohibin-1 can predict renal functional deterioration in patients with renal disorders.
Urinary and plasma levels of vasohibin-1 can predict renal functional deterioration in patients with renal disorders.
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DOI：
10.1371/journal.pone.0096932
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Makino H
中科院分区：
文献类型：
--
作者：
Hinamoto N;Maeshima Y;Saito D;Yamasaki H;Tanabe K;Nasu T;Watatani H;Ujike H;Kinomura M;Sugiyama H;Sonoda H;Sato Y;Makino H
血管收缩素-1（VASH-1）是血管生成的负反馈调节因子，小分子血管收缩素结合蛋白（SVBP）作为其分泌伴侣参与其抗血管生成作用。在本研究中，我们的目的是确定VASH-1和SVBP在慢性肾脏病（CKD）患者中的临床意义。我们招募了67名日本住院的肾脏疾病患者（n = 45）或无（n = 22）肾活检样本和10名日本健康对照。 我们评估了血浆和尿液中VASH-1/VASH-1-SVBP复合物/SVBP水平与临床病理参数之间的相关性。血浆VASH-1水平与年龄、收缩压和舒张压呈负相关，与新月体形成呈正相关。血浆和尿液中VASH-1和VASH-1-SVBP复合物水平升高与肾脏预后不良显著相关。这些结果表明尿和血浆VASH-1水平升高与肾功能进行性下降之间存在相关性，从而表明VASH-1在预测肾病（包括CKD）患者的肾脏预后不良方面具有潜在作用。
Vasohibin-1 (VASH-1) is a negative feedback regulator of angiogenesis, and a small vasohibin-binding protein (SVBP) serves as its secretory chaperone and contributes to its antiangiogenic effects. In the present study, we aimed to define the clinical significance of VASH-1 and SVBP in patients with chronic kidney disease (CKD). We recruited 67 Japanese hospitalized patients with renal disorders with (n = 45) or without (n = 22) renal biopsy samples and 10 Japanese healthy controls. We evaluated the correlations between the plasma and urinary levels of VASH-1/VASH-1-SVBP complex/SVBP and the clinicopathological parameters. The plasma levels of VASH-1 were inversely correlated with age and systolic and diastolic blood pressure and positively correlated with crescent formation. Increased plasma and urinary levels of VASH-1 and VASH-1-SVBP complex were significantly correlated with worse renal outcomes. These results demonstrate an association between elevated urinary and plasma levels of VASH-1 and progressive decline of the renal function, thus suggesting a potential role for VASH-1 in predicting a worse renal prognosis in patients with renal disease, including CKD.
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