Meta-analysis of 16 studies of the association of alcohol with colorectal cancer
Meta-analysis of 16 studies of the association of alcohol with colorectal cancer
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DOI：
10.1002/ijc.32377
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发表时间：
2020-02-01
影响因子：
6.4
通讯作者：
Peters, Ulrike
中科院分区：
文献类型：
--
作者：
McNabb, Sarah;Harrison, Tabitha A.;Peters, Ulrike
饮酒是结直肠癌（CRC）的一个既定风险因素。然而，尽管研究一直报告重度饮酒者患CRC的风险升高，但适度饮酒的相关性尚不清楚。我们对16项CRC研究进行了综合分析，以检查酒精-CRC关联的形状，调查该关联的潜在效应调节剂，并检查癌症解剖部位和阶段的酒精消费的差异效应。我们收集了来自5个病例对照和11个巢式病例对照研究的14，276例CRC病例和15，802例对照的饮酒信息。我们比较了线性和限制性三次样条的调整逻辑回归模型，以选择最适合饮酒和CRC之间关联的模型。使用固定效应荟萃分析汇总研究特定结果。与非/偶尔饮酒相比（
Alcohol consumption is an established risk factor for colorectal cancer (CRC). However, while studies have consistently reported elevated risk of CRC among heavy drinkers, associations at moderate levels of alcohol consumption are less clear. We conducted a combined analysis of 16 studies of CRC to examine the shape of the alcohol-CRC association, investigate potential effect modifiers of the association, and examine differential effects of alcohol consumption by cancer anatomic site and stage. We collected information on alcohol consumption for 14,276 CRC cases and 15,802 controls from 5 case-control and 11 nested case-control studies of CRC. We compared adjusted logistic regression models with linear and restricted cubic splines to select a model that best fit the association between alcohol consumption and CRC. Study-specific results were pooled using fixed-effects meta-analysis. Compared to non-/occasional drinking (