Pilot study of whole-blood gamma interferon response to the Vibrio cholerae toxin B subunit and resistance to enterotoxigenic Escherichia coli-associated diarrhea.
Pilot study of whole-blood gamma interferon response to the Vibrio cholerae toxin B subunit and resistance to enterotoxigenic Escherichia coli-associated diarrhea.
复制标题
全血γ干扰素对霍乱弧菌毒素B亚基反应和对产肠毒素大肠杆菌相关性腹泻的抵抗力的初步研究。
DOI：
10.1128/cvi.00486-09
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Okhuysen,PabloC
中科院分区：
文献类型：
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作者：
Flores,Jose;DuPont,HerbertL;Paredes-Paredes,Mercedes;Aguirre-Garcia,MMagdalena;Rojas,Araceli;Gonzalez,Alexei;Okhuysen,PabloC
EnterotoxigenicEscherichia coli(ETEC), which produces heat-labile toxin (LT), is a common cause of travelers' diarrhea (TD). The B subunit of ETEC LT is immunologically related to the B subunit ofVibrio choleraetoxin (CT). In this pilot study we evaluated the whole-blood gamma interferon response to CT B in 17 U.S. adults traveling to Mexico. Only one of nine subjects who demonstrated a cellular immune response as determined by whole-blood gamma interferon production to CT B on arrival to Mexico developed diarrhea, whereas five of eight without a cellular response developed diarrhea. Markers of the cellular immune response to ETEC LT could help in identifying individuals immune to ETEC LT, and these markers deserve additional study.
