MONONUCLEAR CELLULAR INFILTRATES IN CLINICALLY INVOLVED SKIN FROM PATIENTS WITH SYSTEMIC-SCLEROSIS OF RECENT-ONSET PREDOMINANTLY CONSIST OF MONOCYTES MACROPHAGES
MONONUCLEAR CELLULAR INFILTRATES IN CLINICALLY INVOLVED SKIN FROM PATIENTS WITH SYSTEMIC-SCLEROSIS OF RECENT-ONSET PREDOMINANTLY CONSIST OF MONOCYTES MACROPHAGES
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DOI：
10.1159/000163933
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发表时间：
1995-01-01
期刊：
影响因子：
5
通讯作者：
JIMENEZ, SA
中科院分区：
文献类型：
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作者：
KRALING, BM;MAUL, GG;JIMENEZ, SA
系统性硬化症（SSc）是一种全身性自身免疫性疾病，其特征是免疫异常、微血管功能障碍和组织纤维化。本研究评价了7例最近发作的SSc患者（平均疾病持续时间为10 +/- 3个月）皮肤中发生的炎症过程，以评估SSc早期单核细胞/巨噬细胞的参与。所有SSc皮肤活检显示炎性微血管内皮细胞活化和纤维化。在新近发作的SSc的受影响皮肤中存在增加数量的浸润性炎性白细胞（p < 0.01），主要由CD 14阳性单核细胞/巨噬细胞组成（p < 0.02）。与正常皮肤（51 +/- 12）相比，SSc皮肤（84 +/- 39）中的CD 3 T淋巴细胞仅轻微升高，但差异无统计学意义。新近发病的SSc的受影响皮肤中的CD 14/CD 3细胞比率（4.0 +/-2.0）显著高于正常皮肤中的（1.4 +/-0.5，p < 0.01）。因此，单核细胞/巨噬细胞是近期发作的SSc皮肤病变中的主要浸润单核细胞。这些结果强烈表明，CD 14阳性单核细胞/巨噬细胞在SSc发病的早期阶段发挥重要作用。
Systemic sclerosis (SSc) is a generalized autoimmune disorder characterized by immunological abnormalities, microvascular dysfunction, and tissue fibrosis. This study evaluated the inflammatory processes occurring in skin of 7 patients with SSc of recent onset (average disease duration of 10 +/- 3 months) to assess the involvement of monocytes/macrophages during the early stages of SSc. All SSc skin biopsies displayed inflammatory microvascular endothelial cell activation and fibrosis. Increased numbers of infiltrating inflammatory leukocytes were present in affected skin of recent onset SSc (p < 0.01) mainly consisting of CD14-positive monocytes/macrophages (p < 0.02). CD3 T lymphocytes were only slightly elevated in SSc skin (84 +/- 39) compared to normal (51 +/- 12), but the differences were statistically not significant. The ratio of CD14/CD3 cells was substantially higher in affected skin of recent onset SSc (4.0 +/- 2.0) than in normal skin (1.4 +/- 0.5, p < 0.01). Monocytes/macrophages, therefore, are the predominant infiltrating mononuclear cell in skin lesions of recent-onset SSc. These results strongly suggest that CD14-positive monocytes/macrophages play an important role during the early stages of SSc pathogenesis.