Expression pattern of cLhx2b, cZic1 and cZic3 in the developing chick diencephalon
Expression pattern of cLhx2b, cZic1 and cZic3 in the developing chick diencephalon
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DOI：
10.1016/s0925-4773(02)00091-6
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发表时间：
2002-07-01
影响因子：
2.6
通讯作者：
Golden, JA
中科院分区：
文献类型：
--
作者：
Lim, Y;Golden, JA
间脑是发育中的前脑的尾部，形成上皮层、丘脑、下丘脑和视网膜。成熟的间脑在功能和解剖上被包裹成清晰的核团。为了了解大脑这一区域是如何发育的，我们研究了几种转录因子在发育过程中的表达。我们发现LIM同源结构域转录因子cLhx2b和锌指转录因子。CZic1和cZic3主要在鸡背侧间脑的部分重叠结构域中表达。有趣的是，它们在早期神经上皮祖细胞中的表达与在发育更高级阶段的分化核中的表达之间存在相关性。(C)2002爱思唯尔科学爱尔兰有限公司。保留所有权利。
The diencephalon is the caudal part of the developing forebrain that gives rise to the epithalamus, thalamus, hypothalamus and retina. The mature diencephalon is functionally and anatomically parceled into well-defined nuclei. In an effort to understand how this region of the brain develops we examined the expression of several transcription factors during development. We find that the LIM homeodomain transcription factor, cLhx2b, and the zinc finger transcription factors. cZic1 and cZic3, are predominantly expressed in partially overlapping domains of the chick dorsal diencephalon. Interestingly, a correlation exists between their expression in neuroepithelial progenitor cells at early stages and in the differentiated nuclei at progressively more advanced stages of development. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.