IMPAIRED MECHANICAL STRENGTH OF BONE IN EXPERIMENTAL COPPER DEFICIENCY
IMPAIRED MECHANICAL STRENGTH OF BONE IN EXPERIMENTAL COPPER DEFICIENCY
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DOI：
10.1159/000177774
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发表时间：
1993-09-01
影响因子：
3.9
通讯作者：
PATERSON, CR
中科院分区：
文献类型：
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作者：
JONAS, J;BURNS, J;PATERSON, CR
铜，通过其作为赖氨酰氧化酶的辅因子的作用，是胶原蛋白中分子内和分子间交联所必需的。在人类和动物中，铜缺乏与归因于有缺陷的交联的骨脆性有关。为了评估铜缺乏动物的骨强度，我们根据生物力学的考虑设计了一个灵敏的扭转测试装置。股骨从7铜缺乏大鼠和他们的配对喂养的控制进行了测试，在扭转负荷，直到骨折。最大持续扭矩（t = 2.93，p < 0.05）、极限角变形（t = 2.52，p < 0.05）和韧性（t = 2.88，p < 0.05）显著降低。在一项补充研究中，结果表明，铜缺乏动物股骨的灰分重量和钙含量与对照动物没有差异。因此，机械强度受损可能与骨胶原成分的缺陷有关。
Copper, through its role as cofactor for lysyl oxidase, is essential for intra- and inter-molecular cross-links in collagen. Copper deficiency, in man and in animals, is associated with bone fragility ascribed to defective cross-links. To assess bone strength in copper-deficient animals, we designed a sensitive torsion-testing apparatus according to biomechanical considerations. Femora from 7 copper-deficient rats and from their pair-fed controls were tested in torsional loading until fracture. Significant decreases in the maximal sustained torque (t = 2.93, p < 0.05), in the ultimate angular deformation (t = 2.52, p < 0.05) and in the toughness (t = 2.88, p < 0.05) were demonstrated. In a complementary study, it was shown that the ash weight and the calcium content of the femora from the copper-deficient animals did not differ from those of the controls. It was likely, therefore, that the impaired mechanical strength was related to defects in the collagen component of bone.