Surface mobility of postsynaptic AMPARs tunes synaptic transmission
Surface mobility of postsynaptic AMPARs tunes synaptic transmission
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DOI：
10.1126/science.1152089
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发表时间：
2008-04-11
期刊：
影响因子：
56.9
通讯作者：
Choquet, Daniel
中科院分区：
文献类型：
--
作者：
Heine, Martin;Groc, Laurent;Choquet, Daniel
AMPA谷氨酸受体(AMPAR)介导快速兴奋性突触传递。在快速连续的突触刺激下，传递可能会被抑制。快速突触抑制的恢复完全归因于递质释放和/或AMPAR脱敏的恢复。我们发现，在完整的海马神经元和培养的神经元中观察到的AMPAR的横向扩散，允许在突触后密度内或附近的脱敏受体与初级功能受体快速交换。在几十毫秒的时间范围内从抑郁中恢复的部分原因可以解释为这种快速的受体交换。通过交联、内源性聚集或钙升高来阻止AMPAR表面移动都会减缓抑郁的恢复。突触后受体运动的生理调节通过影响突触反应的频率依赖性来影响突触传递的保真度。
AMPA glutamate receptors (AMPARs) mediate fast excitatory synaptic transmission. Upon fast consecutive synaptic stimulation, transmission can be depressed. Recuperation from fast synaptic depression has been attributed solely to recovery of transmitter release and/or AMPAR desensitization. We show that AMPAR lateral diffusion, observed in both intact hippocampi and cultured neurons, allows fast exchange of desensitized receptors with naive functional ones within or near the postsynaptic density. Recovery from depression in the tens of millisecond time range can be explained in part by this fast receptor exchange. Preventing AMPAR surface movements through cross-linking, endogenous clustering, or calcium rise all slow recovery from depression. Physiological regulation of postsynaptic receptor mobility affects the fidelity of synaptic transmission by shaping the frequency dependence of synaptic responses.