Does gabapentin have an analgesic effect on background, movement and referred pain? A randomised, double-blind, placebo controlled study
Does gabapentin have an analgesic effect on background, movement and referred pain? A randomised, double-blind, placebo controlled study
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DOI：
10.1163/156856901753420945
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发表时间：
2001-01-01
期刊：
影响因子：
--
通讯作者：
McCleane, GJ
中科院分区：
文献类型：
--
作者：
McCleane, GJ
目的：建立口服加巴喷丁对背景，运动和涉及的疼痛在人类subjects. Methods：一个随机，双盲，安慰剂对照研究80例成人患者腰痛和相关的涉及腿疼痛的影响。测量基线疼痛评分;积极治疗是加巴喷丁的剂量增加到1200毫克，每天超过6周的时间，安慰剂组接受相同数量的非活性胶囊。0-10在整个研究期间，每天记录疼痛数值评分（背景、运动和牵涉疼痛），沿着测量活动性和伴随的止痛剂消耗。在背景疼痛方面，疼痛评分从基线记录到第8周没有变化。加巴喷丁8周后使牵涉痛减少0.45（p < 0.05），运动痛减少0.47（p < 0.05）。有没有变化的流动性评分和镇痛药的消耗量仅略有减少，通过使用加巴喷丁（0.45片，每天，p = 0.05）。结论：加巴喷丁的剂量增加到1200毫克，每天对背景疼痛没有影响，只有轻微的影响，涉及疼痛和疼痛的运动。
Aim: to establish the effect of oral gabapentin on background, movement and referred pain in human subjects.Method: a randomised, double-blind, placebo controlled study of 80 adult patients with low back pain and associated referred leg pain. Baseline pain scores were measured; active treatment was with a dose of gabapentin increasing to 1200 mg daily over a six week period, the placebo group receiving an equal number of inactive capsules. 0-10 numerical pain scores were recorded daily throughout the study period (background, movement and referred pain), along with a measure of mobility and concomitant analgesic consumption.Results: 65 subjects provided results. There was no change in pain scores from baseline recordings to week 8 in terms of background pain. Gabapentin reduced referred pain by 0.45 after 8 weeks (p < 0.05) and movement pain by 0.47 (p < 0.05). There were no changes in mobility scores and analgesic consumption was only marginally reduced by use of gabapentin (0.45 tablets per day, p = 0.05).Conclusion: gabapentin in a dose increasing to 1200 mg per day has no effect on background pain and only a marginal effect on referred pain and pain on movement.