A QUANTITATIVE MEASURE OF THE ELECTRICAL-ACTIVITY OF HUMAN ROD PHOTORECEPTORS USING ELECTRORETINOGRAPHY
A QUANTITATIVE MEASURE OF THE ELECTRICAL-ACTIVITY OF HUMAN ROD PHOTORECEPTORS USING ELECTRORETINOGRAPHY
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DOI：
10.1017/s0952523800000468
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发表时间：
1990-10-01
影响因子：
1.9
通讯作者：
BIRCH, DG
中科院分区：
文献类型：
--
作者：
HOOD, DC;BIRCH, DG
从角膜记录的电势，即ERG的a波，通过将其行为与从杆状光感受器的体外记录中得出的模型进行比较，作为人类光感受器活动的测量来评估。ERG的前缘表现出该模型预测的线性和非线性行为。在体内记录人类光感受器电活动的能力为评估人类正常和异常受体活动开辟了新的途径。此外，受体反应的定量模型可用于分离视网膜内部的贡献，Granit's PII，对总ERG。基于这一分析，使用b波的波谷到峰值振幅作为内核层活动振幅的代理的做法进行了评估。
An eletrical potential recorded from the cornea, the a-wave of the ERG, is evaluated as a measure of human photoreceptor activity by comparing its behavior to a model derived from in vitro recordings from rod photoreceptors. The leading edge of the ERG exhibits both the linear and nonlinear behavior perdicted by this model. The capability for recording the electrical activity of humans photoreceptors in in vivo opens new avenues for assessing normal and abnormal receptor activity in humans. Furthermore, the quantitative model of the receptor response can be used to isolate the inner retinal contribution, Granit's PII, to the gross ERG. Based on this analysis, the practice of using the trough-to-peak amplitude of the b-wave as a proxy for the amplitude of the inner nuclear layer activity is evaluated.