Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials
Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials
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DOI：
10.1093/ajcn/75.6.1062
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发表时间：
2002-06-01
影响因子：
7.1
通讯作者：
Allen, LH
中科院分区：
文献类型：
--
作者：
Brown, KH;Peerson, JM;Allen, LH
背景：已经开展了多项研究来评估补锌对儿童生长发育的影响。这些研究的结果不一致，导致这些不同结果的因素尚不清楚。目的：因此完成了随机对照干预试验的荟萃分析，以评估补锌对青春期前儿童体格发育和血清锌浓度的影响。设计：通过MEDLINE(国家医学图书馆，贝塞斯达，MD)检索和其他方法，共筛选出33项具有适当数据的可接受研究。结果：补锌对身高、体重、身高体重和血清锌浓度的影响分别为0.350(95%CI：0.189，0.511)和0.309(0.178，0.439)。锌对身高体重指数无显著影响[加权平均效应大小：-0.018(-0.132，0.097)]。补锌使儿童血清锌浓度显著升高，其效应大小为0.820(0.499，1.14)。低初始年龄体重z分数的儿童和初始年龄身高z分数低的6个月大的儿童的生长反应更大。结论：在锌缺乏的危险人群中应考虑改善儿童锌营养的干预措施，特别是在低体重或发育迟缓发生率较高的人群中。人群平均血清锌浓度是儿童锌补充剂成功投放和吸收的有用指标。
Background: Multiple studies have been carried out to assess the effect of zinc supplementation on children's growth. The results of these studies are inconsistent, and the factors responsible for these varied outcomes are unknown.Objective: Meta-analyses of randomized controlled intervention trials were therefore completed to assess the effect of zinc supplementation on the physical growth and serum zinc concentrations of prepubertal children.Design: A total of 33 acceptable studies with appropriate data were identified by MEDLINE (National Library of Medicine, Bethesda, MD) searches and other methods. Weighted mean effect sizes (expressed in SD units) were calculated for changes in height, weight, weight-for-height, and serum zinc concentration by using random-effects models factors associated with effect sizes were explored by meta-regression techniques.Results: Zinc supplementation produced highly significant, positive responses in height and weight increments, with effect sizes of 0.350 (95% CI: 0.189, 0.511) and 0.309 (0.178, 0.439), respectively. There was no significant effect of zinc on weight-for-height indexes [weighted mean effect size: -0.018 (-0.132, 0.097)]. Zinc supplementation caused a large increase in the children's serum zinc concentrations, with an effect size of 0.820 (0.499, 1.14). Growth responses were greater in children with low initial weight-for-age z scores and in those aged >6 mo with low initial height-for-age z scores.Conclusions: Interventions to improve children's zinc nutriture should be considered in populations at risk of zinc deficiency, especially where there are elevated rates of underweight or stunting. The population mean serum zinc concentration is a useful indicator of the successful delivery and absorption of zinc supplements in children.