Daily Meal Anticipation: Interaction of Circadian and Interval Timing a
Daily Meal Anticipation: Interaction of Circadian and Interval Timing a
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每日膳食预期：昼夜节律和间隔时间的相互作用
DOI：
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发表时间：
1984
影响因子：
5.2
通讯作者：
Amy Waring
中科院分区：
文献类型：
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作者：
M. Terman;J. Gibbon;S. Fairhurst;Amy Waring
短间隔和昼夜节律计时系统都支持在食物强化之前的预期反应加速。在第一种情况下，行为模式由具有任意重置属性的标量计时过程确定。相比之下，在每日的食物供应周期中，行为反映了一种自我维持的振荡。以大鼠为实验对象，在没有昼夜照明循环的情况下，通过在昼夜节律基线上添加餐前听觉线索，研究了两种计时的并发操作。在分钟和小时范围内的线索都有助于降低餐前预期反应的水平，尽管指数加速与未提示的情况相似。在分钟范围内的线索产生了反映近似叠加的间隔计时函数。小时范围内的线索在一开始就抑制了反应，与线索持续时间成正比。当其中一个较短的信号突然延长时，短间隔加速出现在不适当的昼夜节律阶段。当餐前提示延长到用餐时间时，预期率显著增加，这表明无论提示持续时间如何，用餐时间开始时的提示终止都是餐前预期的有力锚点。通过使用没有外部提示的用餐遗漏探针，峰值率位于预期用餐时间开始后，通常接近其结束。结果表明标量间隔计时器和昼夜节律预期计时器之间存在相互作用，由昼夜节律自由运行计时器调节。
Both short-interval and circadian timing systems support anticipatory response accelerations prior to food reinforcement. In the first case, the behavior pattern is determined by a scalar timing process with an arbitrary-reset property. In contrast, under daily cycles of food-availability, behavior reflects a self-sustaining oscillation. With rats as subjects, the concurrent operation of timing of both kinds was studied by addition of premeal auditory cues on the circadian baseline, in the absence of a day-night illumination cycle. Cues within both minute and hour ranges served to lower the level of premeal anticipatory responding, although exponential accelerations were similar to the uncued case. Cues within the minutes range yielded interval-timing functions that reflected approximate superposition. Cues within the hours range suppressed respondings at their outset, in proportion to cue duration. When one of the shorter cues was suddenly lengthened, short-interval accelerations appeared at inappropriate circadian phases. When a premeal cue was extended through mealtime, anticipation rates increased markedly, suggesting that cue termination at the start of mealtime is a potent anchor for premeal anticipation regardless of cue duration. By use of meal-omission probes without external cues, peak rates were located after the onset of expected mealtime, often near its termination. The results suggest interactions between the scalar interval timer and the circadian anticipation timer, as modulated by the circadian free-run timer.