Effect of age on carotid arterial intima-media thickness in childhood
Effect of age on carotid arterial intima-media thickness in childhood
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DOI：
10.1007/s00380-004-0766-8
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发表时间：
2004-07-01
影响因子：
1.5
通讯作者：
Yamaguchi, I
中科院分区：
文献类型：
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作者：
Ishizu, T;Ishimitsu, T;Yamaguchi, I
为了研究颈动脉内膜中层厚度 (IMT) 与儿童年龄之间的关系，我们对 60 名健康儿童（27 名男孩，33 名女孩；年龄范围，5-14 岁）进行了高分辨率颈动脉超声检查，这些儿童通过筛查确定没有血脂异常或高血压。没有发现斑块形成，IMT（IMT 均方根粗糙度）的不规则性与年龄无关。平均 IMT 随年龄呈线性增加 [IMT（毫米）=（0.009 x 年龄（岁）+ 0.35]（r = 0.39，P = 0.002）。在调整性别、父母吸烟、收缩压和舒张压、体重指数以及低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯的血清浓度后，这种相关性仍然显着。这些已知的成人心血管疾病危险因素均与儿童年龄调整 IMT 没有显着关系。虽然周壁应力和舒张压与年龄无关，但平均 IMT 和管腔直径与循环血量呈显着正相关，循环血量是根据身高和体重计算的。这些数据表明，年龄依赖性的动脉壁生理性增厚始于儿童期。
To investigate relationships between carotid arterial intima-media thickness (IMT) and age in childhood, we performed high-resolution carotid arterial ultrasonography in 60 healthy children (27 boys, 33 girls; age range, 5-14 years) determined by screening to have no dyslipidemia or hypertension. No plaque formation was found, and irregularity of IMT (root mean square roughness of IMT) did not correlate with age. Mean IMT increased in a linear manner with age [IMT in millimeters = (0.009 x age in years) + 0.35] (r = 0.39, P = 0.002). This correlation remained significant after adjustment for gender, parental smoking, systolic and diastolic blood pressure, body mass index, and serum concentrations of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides. None of these known cardiovascular disease risk factors in adults had a significant relationship with age-adjusted IMT in children. While circumferential wall stress and diastolic blood pressure were not correlated with age, mean IMT and lumen diameter showed significant positive relationships with circulating blood volume, which was calculated as the function of height and weight. These data suggested that age-dependent physiologic thickening of arterial walls begins in childhood.