Circulating microRNAs as potential biomarkers of HBV infection persistence
Circulating microRNAs as potential biomarkers of HBV infection persistence
复制标题
循环 microRNA 作为 HBV 感染持续性的潜在生物标志物。
DOI：
10.1016/j.meegid.2017.06.023
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发表时间：
2017-10-01
影响因子：
3.2
通讯作者：
Wang, Lanlan
中科院分区：
文献类型：
--
作者：
Chen, Jie;Wu, Xiaojuan;Wang, Lanlan
目的：目的：比较B型肝炎病毒（HBV）感染者与病毒自然清除者的microRNA（miRNA）表达谱差异，寻找新的诊断和治疗评价指标。结果：miR-29 b、miR-34、miR-4485、miR-3180、miR-125、miR-330- 3 p、miR-1468在自发清除组和慢性乙型肝炎组中的表达差异有统计学意义（P < 0. 05）。miR-29 b、miR-34、miR-4485在CHB组中明显升高，而miR-125、miR-330- 3 p、miR- 1468、miR-3180在CHB组中明显降低。结论：以上结果提示miR-29 b可能与HBV感染持续性有关，为寻找潜在的HBV感染生物标志物提供了新的思路。(C)2017爱思唯尔B. V.保留所有权利。
Objectives: To investigate different microRNA (miRNA) expression profile in patients of hepatitis B virus (HBV) infection compared with virus spontaneous clearance ones, and try to find new biomarker for diagnosis and treatment assessment.Methods: miRNA expression profiling was analyzed in patients with HBV infection and patients with virus spontaneous clearance by Affymetrix Gene Chip miRNA 4.0 Arrays. The differently expressed miRNAs, as verified by RT-PCR, were analyzed and compared with each other in the two groups of patients.Results: Significant difference was found in the expression of miR-29b, miR-34, miR-4485, miR-3180, miR-125, miR-330-3p, miR-1468 in spontaneous clearance group and CHB group. miR-29b, miR-34, miR-4485 was significantly increased in CHB group, while miR-125, miR-330-3p, miR- 1468, miR-3180 was significantly decreased. Correlation analysis indicate only miR-29b was positive correlation with HBsAg.Conclusions: These results indicated above miRNAs may be associated with HBV infection persistence, and provided us new ideas for finding potential biomarkers. (C) 2017 Elsevier B.V. All rights reserved.