Treatment of rheumatoid synovitis of the knee with intraarticular injection of dysprosium 165-ferric hydroxide macroaggregates.
Treatment of rheumatoid synovitis of the knee with intraarticular injection of dysprosium 165-ferric hydroxide macroaggregates.
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关节内注射镝165-氢氧化铁大聚集体治疗膝关节类风湿性滑膜炎。
DOI：
10.1002/art.1780290201
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发表时间：
1986
影响因子：
--
通讯作者：
Anderson,RJ
中科院分区：
文献类型：
--
作者：
Sledge,CB;Zuckerman,JD;Zalutsky,MR;Atcher,RW;Shortkroff,S;Lionberger,DR;Rose,HA;Hurson,BJ;LankennerJr,PA;Anderson,RJ
对93例血清阳性类风湿关节炎合并持续性膝滑膜炎患者中的108个膝关节进行了关节内注射270 mCi氢氧化铁大聚合体结合镝165治疗。注入接头的放射性泄漏极小。注射后3 h静脉血平均渗漏量为注射剂量的0.11%；这相当于全身平均剂量为0.2拉德。注射后24小时肝脏平均渗漏率为注射剂量的0.64%；这相当于平均肝剂量为3.2拉德。在另外7例患者中，在腹股沟引流淋巴结中发现了可忽略或接近可忽略的活动。对74例膝关节（63例）进行了1年的随访。61%的膝关节效果良好，23%效果尚可，16%效果不佳。放射分期与治疗反应有直接的相关性。在I期影像学改变的膝关节中，72%的患者表现出良好的结果；93%的人表现出改善。在II期改变的膝关节中，59%的患者表现出良好的效果；81%的人表现出改善。这些初步结果表明，165 -氢氧化铁大聚体镝是一种有效的放射滑膜切除术药物。所观察到的低泄漏率与以前使用的药剂相比具有明显的优势。
One hundred eight knees of 93 patients with seropositive rheumatoid arthritis and persistent synovitis of the knee were treated with an intraarticular injection of 270 mCi of dysprosium 165 bound to ferric hydroxide macroaggregate. Leakage of radioactivity from the injected joint was minimal. Mean leakage to the venous blood 3 hours after injection was 0.11% of the injected dose; this corresponds to a mean whole body dose of 0.2 rads. Mean leakage to the liver 24 hours after injection was 0.64% of the injected dose; this corresponds to a mean liver dose of 3.2 rads. In 7 additional patients examined, there was negligible or near negligible activity found in the draining inguinal lymph nodes. One‐year followup was possible for 74 knees (63 patients). Sixty‐one percent of the knees had good results, 23% had fair results, and 16% had poor results. There was a direct correlation between the radiographic stage and response to treatment. In knees with stage I radiographic changes, 72% showed good results; 93% showed improvement. In knees with stage II changes, 59% showed good results; 81% showed improvement. These preliminary results indicate that dysprosium 165‐ferric hydroxide macroaggregate is an effective agent for radiation synovectomy. The low leakage rates observed offer a definite advantage over agents previously used.