DISTRIBUTION OF GALANIN-IMMUNOREACTIVE CELLS WITHIN SEXUALLY DIMORPHIC COMPONENTS OF THE MEDIAL PREOPTIC AREA OF THE MALE AND FEMALE RAT
DISTRIBUTION OF GALANIN-IMMUNOREACTIVE CELLS WITHIN SEXUALLY DIMORPHIC COMPONENTS OF THE MEDIAL PREOPTIC AREA OF THE MALE AND FEMALE RAT
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DOI：
10.1016/0006-8993(93)90164-i
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发表时间：
1993-08-27
期刊：
影响因子：
2.9
通讯作者：
MILLS, R
中科院分区：
文献类型：
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作者：
BLOCH, GJ;ECKERSELL, C;MILLS, R
高比例的甘丙肽免疫反应（GAL-1）细胞的内侧视前区（MPOA）的性二态性成分的大鼠也集中雌激素和GAL内的内侧视前核（MPN）微注射促进睾酮引发后的男性性行为。因此，我们确定了MPOA内GAL-1细胞的分布及其对性腺类固醇的反应。我们报道了去性腺的雄性动物的内侧视前核（MPNc）中央部的GAL-1细胞数量显著多于雌性动物，而前腹侧室周核（AVPv）内的GAL-1细胞数量显著少于雌性动物; AVPv内的GAL-1细胞数量和密度在完整的，睾酮或雌激素处理的雄性与性腺切除的雄性相比，以及MPNc内的GAL-1细胞数量和密度以及MPN内侧分裂内的GAL-1细胞密度（MPNm），在两种性别的大鼠中，性腺类固醇显著增加。结果表明，在性二形，性腺类固醇敏感功能的调节中的MPOA内的甘丙肽能细胞的参与。
A high percentage of galanin-immunoreactive (GAL-1) cells within sexually dimorphic components of the medial preoptic area (MPOA) of the rat also concentrate estrogen and GAL microinjected within the medial preoptic nucleus (MPN) facilitates masculine sexual behavior after testosterone priming. Thus, we determined the distribution of GAL-1 cells within the MPOA and their response to gonadal steroids. We report significantly greater numbers of GAL-1 cells within the central division of the medial preoptic nucleus (MPNc) and fewer within the anteroventral periventricular nucleus (AVPv), of the gonadectomized male than the gonadectomized female; that GAL-1 cell numbers and densities within the AVPv are increased significantly in the intact, testosterone- or estrogen-treated male compared to the gonadectomized male and that GAL-1 cell numbers and densities within the MPNc and GAL-1 cell densities within the medial division of the MPN (MPNm), are increased significantly by gonadal steroids in rats of both sexes. The results suggest an involvement of galaninergic cells within the MPOA in the regulation of sexually dimorphic, gonadal steroid sensitive functions.